膀胱癌纳米给药系统研究进展  

Advances in nano-drug delivery systems for bladder cancer

作　　者：齐玲玲 高钟镐 黄伟 QI Ling-ling;GAO Zhong-gao;HUANG Wei(Beijing Key Laboratory of Drug Delivery Technology and Novel Formulations,Department of Pharmaceutics,Institute of Materia Medica,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100050,China)

机构地区：[1]中国医学科学院北京协和医学院药物研究所药物制剂研究室,药物传输技术及新型制剂北京市重点实验室,北京100050

出　　处：《国际药学研究杂志》2020年第11期907-913,共7页Journal of International Pharmaceutical Research

基　　金：十三五“重大新药创制”国家科技重大专项资助项目(2018ZX09711001-002-005);中国医学科学院医学与健康科技创新工程重大协同创新项目(CAMS-2019-I2M-1-005)。

摘　　要：膀胱癌是泌尿系统常见的恶性肿瘤之一。传统的膀胱癌治疗复发率高、副作用大,因此需要更有效的治疗方法。纳米给药系统为膀胱癌的治疗带来了新的曙光。本文就近年来针对膀胱癌报道的纳米给药系统的类型进行综述,主要包括靶向给药系统、抑制血管生成、抗多药耐药、免疫检查点干扰以及光动力学治疗五个方面。Bladder cancer is one of the common malignant tumors in the urinary system.Traditional bladder cancer treatment has a high recurrence rate and large side effects,and thus more effective treatment methods are required.Nano-drug delivery systems bring a new light to the treatment of bladder cancer.This article reviews the types of nano-drug delivery systems for bladder cancer,re⁃ported in recent years,in terms of the targeted drug delivery systems,inhibition of angiogenesis,anti-multidrug resistance,immune checkpoint interference,and photodynamic therapy.

关 键 词：膀胱癌 纳米给药系统 靶向治疗 光动力学治疗 

分 类 号：R944[医药卫生—药剂学]