锦灯笼中酸浆苦素类成分的分离与鉴定  

Study on the isolation and identification of the chemical constituents of physalins in Physalis alkekengi L.var.franchetii(Mast.)Makino

作　　者：夏天乙 钟仁兴 丁子禾 杨燕妮 王武静 王毅 刘禹熙 商立峰 舒尊鹏 XIA Tianyi;ZHONG Renxing;DING Zihe;YANG Yanni;WANG Wujing;WANG Yi;LIU Yuxi;SHANG Lifeng;SHU Zunpeng(Guangdong Standardized Processing Engineering Technology Research Center of Traditional Chinese Medicine,Guangzhou 510006,China;Department of Traditional Chinese Medicine,Guangdong Pharmaceutical University,Guangzhou 510006,China;Guangzhou Feng Hua Shu Bao Biological Technology Co.LTD,Guangzhou 510006,China;Guangdong Andao Medical Equipment Co.LTD,Foshan 528200,China)

机构地区：[1]广东省中药饮片规范化炮制工程技术研究中心,广东广州510006 [2]广东药科大学中药学院,广东广州510006 [3]广州峰华舒宝生物科技有限公司,广东广州510006 [4]广东安道医疗器械有限公司,广东佛山528200

出　　处：《广东药科大学学报》2020年第6期761-764,共4页Journal of Guangdong Pharmaceutical University

基　　金：广州市科技计划基础与应用基础研究项目(202002030226);中国博士后基金面上项目(2017M610816);国家自然科学基金资助项目(81603366)。

摘　　要：目的对锦灯笼中的酸浆苦素类(physalin)成分进行分离与鉴定。方法采用ODS反相柱色谱、硅胶柱色谱以及HPLC等方法进行分离,运用综合波谱学技术进行化合物结构鉴定。结果从锦灯笼的50%乙醇提取物中分离得到7个酸浆苦素类化合物,分别为酸浆苦素D(1)、酸浆苦素E(2)、酸浆苦素B(3)、酸浆苦素N(4)、酸浆苦素O(5)、酸浆苦素G(6)、酸浆苦素P(7)。结论共分离得到7个化合物,并进行了详细的结构解析和更全面的NMR归属。Objective To study the isolation and identification of the chemical constituents of the physalin in Physalis alkekengi L.var.franchetii(Mast.)Makino.Methods The constituents were separated by ODS reverse phase column chromatography,silica gel column chromatography and HPLC methods.The constituents were identified by modern spectroscopic techniques.Results Seven compounds were isolated from 50%ethanol extract of Physalis alkekengi L.var.franchetii(Mast.)Makino and identified as physalin D(1),physalin E(2),physalin B(3),physalin N(4),physalin O(5),physalin G(6),physalin P(7).Conclusion Seven compounds have been isolated and analyzed in detail and their NMR assignments have been more comprehensive.

关 键 词：锦灯笼 酸浆苦素 成分 分离 结构鉴定 

分 类 号：R284.2[医药卫生—中药学]