高密度脂蛋白组分修饰参与动脉粥样硬化发生发展的研究进展  

Research progress on the modification of high density lipoprotein components in atherosclerosis

作　　者：司艳红 邵波 赵敏 李英 张先哲 张颖 秦树存 SI Yanhong;SHAO Bo;ZHAO Min;LI Ying;ZHANG Xianzhe;ZHANG Ying;QIN Shucun(Shandong First Medical University&Shandong Academy of Medical Sciences,Taian,Shandong 271000,China)

机构地区：[1]山东第一医科大学山东省医学科学院,山东省泰安市271000

出　　处：《中国动脉硬化杂志》2020年第12期1089-1094,共6页Chinese Journal of Arteriosclerosis

基　　金：国家自然科学基金(81600681);山东省泰山学者岗位专项科研基金(ts201511057);山东省重点研发计划项目(2019GSF108260)。

摘　　要：高密度脂蛋白(HDL)作为体内保护心血管系统的重要物质,可通过多种途径拮抗动脉粥样硬化(As)进展。然而,在病理状态下,氧化、糖化、甲基化修饰及微小核糖核酸(miRNA)修饰可引起HDL组分出现结构改变和功能障碍。本文重点综述了HDL功能组分及其修饰与As关系研究进展,此方面研究对于探寻As诊断和治疗潜在靶点具有重要意义。High density lipoprotein(HDL), as an important substance to protect cardiovascular system in vivo, can inhibit the progression of atherosclerosis(As) through various pathways. However, in pathological state, oxidation, glycosylation, methylation and miRNA modification can result in the structural changes and dysfunction of HDL. This review focuses on the research progress of HDL active components and their modification in As, which is of great significance for the exploration of potential targets in As diagnosis and treatment.

关 键 词：高密度脂蛋白 动脉粥样硬化 微小核糖核酸 载脂蛋白AI 对氧磷脂酶1 1-磷酸鞘氨醇 

分 类 号：R5[医药卫生—内科学]