儿童哮喘严重程度与体重指数、脂联素和瘦素的关系  

Correlation of severity of asthma in children with body mass index,adiponectin and leptin

作　　者：王琴 傅俊健 杨梅[2] 周春 WANG Qin;FU Jun-jian;YANG Mei;ZHOU Chun(Department of Pediatrics,Nanjing Hospital of Integrated Traditional Chinese and Western Medicine,Nanjing 210014,China;Department of Pediatrics,Jianhu Hospital Affiliated to Nantong University,Jianhu,Jiangsu 224700,China)

机构地区：[1]南京市中西医结合医院儿科,江苏南京210014 [2]南通大学附属建湖医院儿科,江苏盐城224700

出　　处：《临床肺科杂志》2021年第1期50-53,共4页Journal of Clinical Pulmonary Medicine

摘　　要：目的本研究旨在探讨儿童哮喘严重程度与体重指数(body mass index,BMI)、脂联素和瘦素的关系,探索这些参数对哮喘严重程度的判断作用。方法纳入2017年6月至2019年6月期间就诊于本院的102例儿童哮喘患者。采用酶联免疫吸附试验(enzyme-linked immunosorbent assay,ELISA)检测脂联素和瘦素。统计分析BMI、脂联素和瘦素与哮喘严重程度的相关性。结果102例儿童哮喘患者,其中对照组50例(BMI≤28 kg/m^2),观察组52例(BMI>28 kg/m^2),观察组重度哮喘患者比例明显多于对照组(28/52 vs.12/50,P<0.05),而轻度哮喘患者比例则明显少于对照组(12/52 vs.23/50,P<0.05)。哮喘不同严重程度与BMI、脂联素和瘦素之间存在显著相关性(r=0.85,P<0.001;r=-0.91,P<0.001;r=0.88,P<0.001),其中脂联素浓度随着哮喘严重程度增加呈下降趋势,而BMI和瘦素则呈升高趋势。BMI、瘦素、脂联素和血压是哮喘患者病情严重程度的独立危险因素(OR=1.122,95%CI:1.021~1.512,P=0.030;OR=1.056,95%CI:1.017~1.311,P=0.012;OR=0.821,95%CI:0.685~0.939,P=0.016;OR=1.023,95%CI:1.004~2.076,P=0.036)。结论儿童哮喘与BMI、脂联素和瘦素相关。BMI和瘦素升高、脂联素水平降低与儿童哮喘患者病情严重相关,对哮喘的病情有一定的预测价值。Objective To explore the relationship of the severity of asthma with body mass index(BMI),adiponectin and leptin in children.Methods 102 children with asthma who visited our hospital from June 2017 to June 2019 were prospectively included.Adiponectin and leptin were detected by enzyme-linked immunosorbent assay(ELISA).The correlation of BMI,adiponectin and leptin with the severity of asthma was analyzed.Results Among 102 children with asthma,there were 50 cases in the control group(BMI≤28 kg/m^2)and 52 cases in the observation group(BMI>28 kg/m^2).The proportion of severe asthma patients in the observation group was significantly higher than that in the control group(28/52 vs.12/50,P<0.05),while the proportion of mild asthma patients was significantly lower than that in the control group(12/52 vs.23/50,P<0.05).There were significant correlation of the severity of asthma with BMI,adiponectin and leptin(r=0.85,P<0.001;r=-0.91,P<0.001;r=0.88,P<0.001).The concentration of adiponectin decreased with the severity of asthma,while BMI and leptin increased.BMI,leptin,adiponectin and blood pressure were independent risk factors for the severity of asthma patients(OR=1.122,95%CI:1.021-1.512,P=0.030;OR=1.056,95%CI:1.017-1.311,P=0.012;OR=0.821,95%CI:0.685-0.939,P=0.016;OR=1.023,95%CI:1.004-2.076,P=0.036).Conclusion Adiponectin,leptin,and BMI are involved in the pathogenesis of asthma in children,suggesting that they might be predictive factors for clinical treatment.

关 键 词：哮喘 脂联素 体重指数 瘦素 儿童 

分 类 号：R725.6[医药卫生—儿科]