临床药师干预感染性眼内炎治疗的效果评价  

Evaluation on the Effects of Clinical Pharmacist's Intervention on the Treatment of Infective Endophthalmitis

作　　者：贾雪松[1] 李乐[2] 罗世伟[2] 陈梦平[3] 王娟[1] JIA Xue-song;LI Le;LUO Shi-wei;CHEN Meng-ping;WANG Juan(Department of Clinical Pharmaceutics Room,Zhengzhou Second People s Hospital,Zhengzhou 450006,China;Department of Clinical Laboratory,Zhengzhou Second People s Hospital,Zhengzhou 450006,China;Department of Ophthalmology,Zhengzhou Second People s Hospital,Zhengzhou 450006,China)

机构地区：[1]郑州市第二人民医院药务科,郑州450006 [2]郑州市第二人民医院检验科,郑州450006 [3]郑州市第二人民医院眼科,郑州450006

出　　处：《中国合理用药探索》2020年第12期35-38,共4页Chinese Journal of Rational Drug Use

基　　金：常州四药临床药学科研基金(CZSYJJ15013)。

摘　　要：目的:探讨临床药师对感染性眼内炎的治疗实施干预措施的临床效果。方法:抽取2013~2017年(无干预组)697例、2018年(有干预组)110例感染性眼内炎的患者病历,对无干预组和有干预组治疗方案、经济指标、细菌耐药的变化等进行统计分析。结果:有干预组多次手术的例数明显下降;药品费用及平均住院天数分别下降了8.16%和15.97%;视力恢复由43.61%升至55.45%;房水和玻璃体液的送检率分别增加了4.56%和16.95%,结膜囊分泌物的标本送检率下降21.51%;经验性治疗方案采纳率由74.32%增加至90.00%、有干预组药敏结果显示革兰阳性菌24株(82.76%),未发现对万古霉素耐药的菌株;革兰阴性菌5株(17.24%),均对头孢他啶敏感。结论:临床药师通过参与临床药物治疗工作,协助医师进行治疗方案的优化,对感染性眼内炎的治疗起到了积极的作用。Objective:To explore the clinical effect of clinical pharmacists intervention on the treatment of infectious endophthalmitis.Methods:The medical records of 697 patients with infectious endophthalmitis from 2013 to 2017(no intervention)and 110 patients with infectious endophthalmitis in 2018(intervention)were selected.The treatment plan,economic indicators and bacterial resistance was analyzed before and after intervention.Results:In the intervention group,the number of cases with multiple operations decreased significantly;Drug costs and average hospital stay decreased by 8.16%and 15.97%respectively;Visual acuity recovery increased from 43.61%to 55.45%;The Inspection rate of aqueous humor and glass fluid increased by 4.56%and 16.95%,and the inspection rate of conjunctival sac secretions decreased by 21.51%;Empiric treatment plan adoption rate increased from 74.32%to 90.00%.After intervention,24 strains of gram-positive bacteria were found(82.76%),with no vancomycin resistant strains found.5 strains of gram-negative bacteria(17.24%)were found,all sensitive to ceftazidine.Conclusion:Clinical pharmacists play an active role in the treatment of infectious endophthalmitis by participating in clinical drug treatment and assisting physicians in the optimization of treatment plan.

关 键 词：眼内炎 感染性 临床药师 干预 耐药 

分 类 号：R969.3[医药卫生—药理学]