手足口病相关肠道病毒A型单克隆中和抗体综述  

Summary of hand, foot and mouth disease-related enterovirus A monoclonal neutralization antibodies

作　　者：朱文兵[1] 董少忠[1] ZHU Wen-Bing;DONG Shao-Zhong(Yunnan Key Laboratory of Vaccine Research&Development on Severe Infections Disease,Institute of Medical Biology,Chinese Academy of Medicine Science and Peking Union Medical College,Kunming 650118,China)

机构地区：[1]中国医学科学院&北京协和医学院医学生物学研究所,云南省重大传染病疫苗研发重点实验室,昆明650118

出　　处：《生命科学》2020年第10期1040-1046,共7页Chinese Bulletin of Life Sciences

基　　金：云南省重大科技专项计划-生物医药重大专项(2018ZF006)。

摘　　要：手足口病(hand foot mouth disease, HFMD)的致病病原体为肠道病毒A型(enterovirus A, EV-A),主要包括肠道病毒71型(enterovirus A 71, EVA71)和柯萨奇病毒(coxsackievirus, CV)(CVA16、CVA6和CVA10)。已上市的EVA71灭活疫苗对不同型别的EV-A不具有交叉保护效力,广谱中和单克隆抗体有望成为预防或治疗手足口病的广谱药物。现就EV-A单克隆抗体的中和作用机制及中和表位进行综述。The causative agent of hand foot mouth disease(HFMD)is enterovirus A(EV-A),which mainly includes enterovirus A 71(EVA71)and coxsackievirus(CV)(CVA16,CVA6 and CVA10).The licensed EVA71 inactivated vaccine poses no cross-protective effect on different types of EV-A,and broad-spectrum drugs are required to prevent or treat HFMD.The neutralization mechanism and neutralizing epitopes of EV-A monoclonal antibodies are reviewed.

关 键 词：手足口病 肠道病毒A型 单克隆抗体 

分 类 号：R373[医药卫生—病原生物学] R392[医药卫生—基础医学]