骨髓间充质干细胞治疗心肌梗死的研究进展  

Research progress of bone marrow mesenchymal stem cells in treatment of myocardial infarction

作　　者：赵丽平 周晨明 李菁菁[3] 徐彦楠[4] ZHAO Liping;ZHOU Chenming;LI Jingjing;XU Yannan(School of Basic Medical,Hebei Medical University,Hebei Province,Shijiazhuang050017,China;Electron microscope Laboratory Center,Hebei Medical University,Hebei Province,Shijiazhuang050017,China;Department of Cell Biology,Hebei Medical University,Hebei Province,Shijiazhuang050017,China;Teaching Experiment Center,Hebei Medical University,Hebei Province,Shijiazhuang050017,China)

机构地区：[1]河北医科大学基础医学院,河北石家庄050017 [2]河北医科大学电镜实验中心,河北石家庄050017 [3]河北医科大学细胞生物学教研室,河北石家庄050017 [4]河北医科大学教学实验中心,河北石家庄050017

出　　处：《中国医药导报》2020年第35期57-60,共4页China Medical Herald

基　　金：河北省卫生和计划生育委员会医学科学研究重点课题(20180694);河北医科大学临床学院省级大学生创新性实验计划项目(202013415011);河北医科大学大学生创新性实验计划项目(USIP2020239)。

摘　　要：心肌梗死是临床上最常见的危重症,严重威胁着人类的健康。骨髓间充质干细胞具有多向分化、易获取、快速增殖、免疫原性低、可移植性强等优点,是治疗心血管疾病的理想种子细胞。骨髓间充质干细胞治疗心肌梗死的机制包括抗炎与抗纤维化,促进新生血管形成,并能进行免疫调节。但在移植的过程中,移植细胞的存活又受移植细胞活性、迁移和归巢等因素的影响。本文就骨髓间充质干细胞的特点及治疗心肌梗死的机制进行如下综述。Myocardial infarction is the most common critical disease in clinic,which is a serious threat to human health.Bone marrow mesenchymal stem cells are ideal seed cells for the treatment of cardiovascular diseases due to their advantages of multidifferentiation,easy access,rapid proliferation,low immunogenicity and strong transplantability.The mechanism of bone marrow mesenchymal stem cells therapy in myocardial infarction includes anti-inflammatory and anti-fibrosis,promoting angiogenesis,and immune regulation.However,in the process of transplantation,the survival of transplanted cells is affected by the activity,migration,homing and other factors of transplanted cells.In this paper,the characteristics of bone marrow mesenchymal stem cells and the mechanism of treating myocardial infarction are summarized as follows.

关 键 词：骨髓间充质干细胞 心肌梗死 细胞治疗 移植 

分 类 号：R541[医药卫生—心血管疾病]