补中益气汤对膀胱活动低下症患者逼尿肌收缩力的影响  

Effect of Buzhong Yiqi Decoction on detrusor contractility in patients with underactive bladder

作　　者：沈建武[1] 张鹏[2] 牟艳嫣 郑卫军[3] 杨小琴 孟军 丁家森 高瞻[1] SHEN Jianwu;ZHANG Peng;MOU Yanyan;ZHENG Weijun;YANG Xiaoqin;MENG Jun;DING Jiasen;GAO Zhan(Department of Urology,Xiyuan Hospital,China Academy of Chinese Medical Sciences,Beijing100091,China;Department of Urology,Beijing Chaoyang Hospital,Capital Medical University,Beijing100043,China;Basic Medical College,Zhejiang Chinese Medical University,Zhejiang Province,Hangzhou310053,China)

机构地区：[1]中国中医科学院西苑医院泌尿外科,北京100091 [2]首都医科大学附属北京朝阳医院泌尿外科,北京100043 [3]浙江中医药大学基础医学院,浙江杭州310053

出　　处：《中国医药导报》2020年第35期144-147,共4页China Medical Herald

基　　金：北京市科技计划课题(Z181100001718046);中国中医科学院基本科研业务费自主选题项目(ZZ11-067)。

摘　　要：目的评价补中益气汤对膀胱活动低下症患者逼尿肌收缩力的影响。方法回顾性分析2015年12月—2019年10月于中国中医科学院西苑医院泌尿外科就诊的49例膀胱活动低下症患者的临床资料,按治疗方法的不同将其分为治疗组(27例)和对照组(22例)。留置导尿管后,对照组口服盐酸坦洛新缓释胶囊,治疗组在对照组的基础上加用补中益气汤,治疗周期为1~6个月。比较两组患者治疗前后的初感尿意量(VFD)、正常尿意量(VND)、最大尿流率(Qmax)、排尿期最大逼尿肌压(Pdet.max)、最大尿流率时逼尿肌压(Pdet.Qmax)、残余尿量(RV)水平。记录两组治疗过程中的不良反应发生情况。结果治疗后,两组Qmax、Pdet.max、Pdet.Qmax水平均高于治疗前,RV均低于治疗前,差异有统计学意义(P<0.05),但两组VFD、VND与治疗前比较差异均无统计学意义(P>0.05)。治疗后,治疗组Qmax、Pdet.max、Pdet.Qmax水平均高于对照组(P<0.05),但治疗后两组VFD、VND、RV比较差异无统计学意义(P>0.05)。治疗过程中两组均无明显不良反应发生。结论补中益气汤治疗膀胱活动低下症效果显著,可有效改善患者逼尿肌活动低下状态。Objective To evaluate the clinical effect of Buzhong Yiqi Decoction in the treatment of detrusor contractility in patients with underactive bladder.Methods The clinical data of 49 patients treated in Department of Urology of Xiyuan Hospital,China Academy of Chinese Medical Sciences from December 2015 to October 2019 was analyzed retrospectively.According to different treatment methods,the patients were divided into treatment group(27 cases)and control group(22 cases).After indwelling catheterization,the control group was treated with Tamsulosin Hydrochloride Sustained Release Capsules,and the treatment group was treated with Buzhong Yiqi Decoction on the basis of the control group.The treatment course was 1-6 months.The differences of volume of first desire to void(VFD),volume of normal desire to void(VND),maximum flow rate(Qmax),maximum detrusor pressure(Pdet.max),detrusor pressure at the time of maximum flow(Pdet.Qmax),residual urine volume(RV)were compared between the two groups.The adverse reactions of the two groups were recorded during the treatment.Results After treatment,the levels of Qmax,Pdet.max and Pdet.Qmax in both groups were higher than those before treatment,and the RV was lower than that before treatment,the differences were statistically significant(P<0.05).While there were no significant differences of VFD and VND in the two groups compared with those before treatment(P>0.05).After treatment,the levels of Qmax,Pdet.max and Pdet.Qmax in the treatment group were all higher than those in the control group(P<0.05),but there were no statistically significant differences of VFD,VND and RV between the two groups(P>0.05).No obvious adverse reactions occurred during the treatment in both groups.Conclusion Buzhong Yiqi Decoction in the treatment of underactive bladder has significant effects,which can effectively improve patients’underactive detrusor.

关 键 词：补中益气汤 膀胱活动低下症 逼尿肌活动低下 尿流动力学检查 最大尿流率 最大尿流率时逼尿肌压 

分 类 号：R694[医药卫生—泌尿科学]