肝硬化患者血清YKL-40水平变化及临床意义  

Changes and clinical significance of serum YKL-40 levels in patients with liver cirrhosis

作　　者：刘丽波[1] 段旭峰 孔学哲 张保茹 王淑辉 李慧[1] 杨婷[1] 冯军[2] LIU Libo;DUAN Xufeng;KONG Xuezhe;ZHANG Baoru;WANG Shuhui;LI Hui;YANG Ting;FENG Jun(Department of Gastroenterology,No.981 Hospital of the Joint Support Force of the Chinese People’s Liberation Army,Hebei Province,Chengde067000,China;Department of Laboratory,Chengde Central Hospital,Hebei Province,Chengde067000,China)

机构地区：[1]中国人民解放军联勤保障部队第九八一医院消化内科,河北承德067000 [2]河北省承德市中心医院检验科,河北承德067000

出　　处：《中国医药导报》2020年第34期119-122,共4页China Medical Herald

基　　金：河北省省级科技计划自筹经费项目(172777124)。

摘　　要：目的研究肝硬化患者血清YKL-40水平变化与临床特征的关系,初步探讨其临床意义。方法选取2016年2月—2018年12月中国人民解放军联勤保障部队第九八一医院诊治的90例肝硬化患者(肝硬化组)及40例健康查体者(对照组)。应用酶联免疫吸附试验检测两组血清YKL-40水平。分析肝硬化患者的血清YKL-40水平与临床特征之间的关系,Pearson线性相关分析肝硬化患者血清YKL-40水平与肝功能指标[血清总胆红素(TBil)、谷丙转氨酶(ALT)、天冬氨酸转氨酶(AST)、白蛋白(Alb)及凝血酶原时间(PT)]之间的相关性。结果肝硬化组TBil、ALT、AST、血清YKL-40水平及PT明显高于对照组,而Alb水平明显低于对照组(均P<0.05)。肝硬化组不同年龄、性别、肝硬化原因的血清YKL-40表达水平比较,差异均无统计学意义(均P>0.05),不同Child-Pugh分级、不同肝纤维化程度、有无并发症的血清YKL-40表达水平比较,差异均有统计学意义(均P<0.05)。肝硬化组血清YKL-40表达水平与血清TBil、PT、ALT、AST呈正相关(r=0.532、0.459、0.572、0.622,均P<0.05),而与血清Alb呈显著负相关(r=-0.513,P<0.05)。结论肝硬化患者血清中YKL-40水平升高,并与患者肝功能Child-Pugh分级、肝纤维化程度、并发症及肝功能指标有关,有望成为新的肝硬化诊断及判断疾病严重程度的指标。Objective To study the relationship between changes in serum YKL-40 levels and clinical characteristics in patients with liver cirrhosis,and to discuss its clinical significance.Methods From February 2016 to December 2018,90 patients with liver cirrhosis(the liver cirrhosis group)and 40 patients with physical examination(the control group)diagnosed and treated in the No.981 Hospital of the Joint Support Force of the Chinese People’s Liberation Army were selected.The level of serum YKL-40 of the two groups was detected by enzyme linked immunosorbent assay(ELISA).The relationship between YKL-40 levels and clinical characteristics were analyzed.The correlation between serum YKL-40 levels and liver function indicators[total bilirubin(TBil),alanine aminotransferase(ALT),aspartate aminotransferase(AST),albumin(Alb),and prothrombin time(PT)]in patients with liver cirrhosis were analyzed by Pearson linear correlation analysis.Results The TBil,ALT,AST,serum YKL-40 levels and PT in the liver cirrhosis group were significantly higher than those in the control group,with Alb level significantly lower than that in the control group(all P<0.05).There were no statistically significant differences in serum YKL-40 expression levels in the liver cirrhosis group with different age,gender and cirrhosis causes(all P>0.05),while there were statistically significant differences in serum YKL-40 expression levels in the liver cirrhosis group with different Child-Pugh grades,different degrees of liver fibrosis,and complications or not(all P<0.05).The expression levels of serum YKL-40 in liver cirrhosis group was positively correlated with serum TBil,PT,ALT and AST(r=0.532,0.459,0.572,0.622,all P<0.05),and significantly negatively correlated with serum Alb(r=-0.513,P<0.05).Conclusion The level of YKL-40 in the serum of patients with liver cirrhosis is increased,and is related to Child-Pugh classification of liver function,liver fibrosis and complications and liver function indexes.It is expected to become a new indicator of liver cirrhos

关 键 词：肝硬化 血清 YKL-40 天冬氨酸转氨酶 

分 类 号：R675.31[医药卫生—外科学]