当归补血汤合二妙散加减联合封闭负压引流技术治疗糖尿病足的效果  

Effect of Danggui Buxue Decoction and Ermiao Powder addition and subtraction combined with vacuum sealing drainage technique on diabetic foot

作　　者：张杨 耿海涛[2] 刘元炜 张丹[3] 王艳 宋蕊 左维维 ZHANG Yang;GENG Haitao;LIU Yuanwei;ZHANG dan;WANG Yan;SONG Rui;ZUO Weiwei(Department of General Medicine,Qinhuangdao Military Hospital,Hebei Province,Qinhuangdao 066000,China;Department of Pain,Qinhuangdao Third Hospital,Hebei Province,Qinhuangdao 066000,China;the First Department of Radiotherapy,Qinhuangdao First Hospital,Hebei Province,Qinhuangdao 066000,China;Department of Respiratory,Qinhuangdao Military Hospital,Hebei Province,Qinhuangdao 066000,China)

机构地区：[1]河北省秦皇岛军工医院综合内科,河北秦皇岛066000 [2]河北省秦皇岛市第三医院疼痛科,河北秦皇岛066000 [3]河北省秦皇岛市第一医院放疗一科,河北秦皇岛066000 [4]河北省秦皇岛军工医院呼吸科,河北秦皇岛066000

出　　处：《中国医药导报》2020年第36期82-86,共5页China Medical Herald

基　　金：河北省中医药管理局中医药类科研计划课题(2020368)。

摘　　要：目的探讨当归补血汤合二妙散加减联合封闭负压引流(VSD)技术治疗糖尿病足(DF)的效果。方法选取2017年9月—2019年10月河北省秦皇岛军工医院80例DF患者作为研究对象,采用随机数字表法分为观察组和对照组,各40例。两组均予以基础治疗+清创换药,于此基础上,对照组予以VSD技术,观察组予以当归补血汤合二妙散加减联合VSD技术。比较两组临床疗效、治疗前后症状改善[皮肤温度、患足疼痛、双足踝肱指数(ABI)]、炎性指标[降钙素原(PCT)、C-反应蛋白(CRP)]及血清胰岛素样生长因子-1(IGF-1)、色素上皮衍生因子(PEDF)水平。结果观察组总有效率高于对照组(P<0.05);治疗后两组皮肤温度较治疗前升高,患足疼痛评分较治疗前降低,观察组治疗后ABI高于治疗前,且观察组治疗后皮肤温度、ABI高于对照组,患足疼痛评分低于对照组(P<0.05);两组治疗后CRP、PCT、PEDF水平较治疗前降低,IGF-1水平较治疗前升高,且观察组治疗后CRP、PCT、PEDF水平低于对照组,IGF-1水平高于对照组(P<0.05)。结论当归补血汤合二妙散加减联合VSD技术首次治疗DF,效果确切,能有效改善临床症状,缩短创面愈合时间,降低炎性水平,调节血清PEDF、IGF-1水平。Objective To explore the effect of Danggui Buxue Decoction combined with Ermiao Powder addition and subtraction combined with vacuum sealing drainage(VSD)technique on diabetic foot(DF).Methods From September 2017 to October 2019,80 patients with DF from Qinhuangdao Military Hospital in Hebei Province were selected as the research subjects,the patients were divided into observation group and control group by random number table method,40 cases in each group.Both groups were given basic treatment+debridement and dressing change.Based on this,the control group was given VSD technology,and the observation group was given Danggui Buxue Decoction and Ermiao Powder addition and subtraction combined with VSD technology.The clinical efficacy,symptom improvement(skin temperature,foot pain,bipedal ankle brachial index[ABI]),inflammatory indicators(procalcitonin[PCT],C-reactive protein[CRP])and serum insulin-like growth factor-1(IGF-1),pigment epithelium-derived factor(PEDF)levels were compared between the two groups before and after treatment.Results The total effective rate of the observation group was higher than that of the control group(P<0.05);after treatment,the skin temperature of the two groups was higher than before,and the pain score of the affected foot was lower than before(P<0.05),the skin temperature and ABI index of the observation group after treatment were higher than the control group,and the pain score of the affected foot was lower than the control group(P<0.05);after treatment,the levels of CRP,PCT and PEDF in both groups were lower than before treatment,and the levels of IGF-1 were higher than before treatment(P<0.05);after treatment,the levels of CRP,PCT and PEDF in the observation group were lower than those in the control group,and the levels of IGF-1 were higher than those in the control group(P<0.05).Conclusion Danggui Buxue Decoction and Ermiao Powder addition and subtraction combined with VSD technology for the first time in the treatment of DF,the effect is definite,can effectively improve clin

关 键 词：当归补血汤 二妙散 封闭负压引流技术 糖尿病足 

分 类 号：R587.1[医药卫生—内分泌]