米拉贝隆治疗输尿管支架管相关症状的效果  

Effect of Mirabegron on ureteral stent-related symptoms

作　　者：杨江华[1] 廖晓星 赵延朋[1] 崔功静 YANG Jianghua;LIAO Xiaoxing;ZHAO Yanpeng;CUI Gongjing(Department of Urology,Beijing Aerospace General Hospital,Beijing 100076,China;Department of Urology,Beijing University of Chinese Medicine Third Affiliated Hospital,Beijing 100029,China)

机构地区：[1]北京航天总医院泌尿外科,北京100076 [2]北京中医药大学第三附属医院泌尿外科,北京100029

出　　处：《中国医药导报》2020年第36期91-94,共4页China Medical Herald

基　　金：北京市科技计划项目(Z171100001017131)。

摘　　要：目的观察米拉贝隆治疗输尿管支架管相关症状(SRSs)的效果。方法选取2019年1月—12月因上尿路结石行经尿道腔内碎石术后留置输尿管支架管的120例患者为研究对象。采取随机数字表法分为研究组和对照组,每组60例。研究组使用米拉贝隆治疗,对照组不使用下尿路症状相关药物。比较两组取管当天国际前列腺症状评分(IPSS)、生活质量(QoL)评分、膀胱状态感知量表(PPBC)评分、疼痛可视化(VAS)评分、镇痛药物使用次数。结果排除失访或采取其他干预措施者,最终入组102人:研究组50人,对照组52人。取出支架管当天,研究组在IPSS(储尿症状)评分、QoL评分、PPBC评分、VAS评分及镇痛药物次数均低于对照组,差异均有统计学意义(均P<0.05);两组IPSS(排尿症状)评分比较,差异无统计学意义(P>0.05)。结论米拉贝隆治疗SRSs效果确切,能够明显减轻储尿期膀胱刺激症状、减少镇痛药物使用。Objective To study the effect of Mirabegron on ureteral stent-related symptoms(SRSs).Methods From January to December 2019,120 cases with indwelling ureteric stents after surgery for upper urinary tract calculi were selected as research subjects.They were divided into the study group and the control group according to random number table method,with 60 cases in each group.The study group was treated with Mirabegron,while the control group did not use any drugs for lower urinary tract symptoms.At the time of stent removal,the international prostate symptom score(IPSS),quality of life(QoL)score,patient perception of bladder condition(PPBC)score,visual analog scale(VAS)score and the amount of analgesics were compared between the two groups.Results Excluded the cases that lost to follow-up or received other treatment options,102 cases completed the study:50 cases in the study group,52 cases in the control group.At the time of stent removal,the scores of IPSS(storage symptoms),QoL,PPBC,VAS and the amount of analgesics in the study group were lower than those in the control group,and the differences were statisticaliy significant(P<0.05);there was no significant difference in the score of IPSS(voiding symptoms)between the two groups(P>0.05).Conclusion Mirabegron has obvious effect on the treatment of SRSs,which can reduce the symptoms of bladder irritation and the amount of analgesic usage.

关 键 词：米拉贝隆 输尿管支架管相关症状 疗效 

分 类 号：R691.4[医药卫生—泌尿科学]