规范硫酸镁用药对重度子痫前期患者妊娠结局的改善作用  

Effect of improvement of standard use of magnesium sulfate in the pregnancy outcomes of patients with severe pre-eclampsia

作　　者：傅菁[1] 许银燕[1] FU Jing;XU Yinyan(Department of Pharmacy,Women’s Hospital of Nanjing Medical University,Nanjing Maternity and Child Health Care Hospital,Jiangsu Province,Nanjing 210004,China)

机构地区：[1]南京医科大学附属妇产医院(南京市妇幼保健院)药学部,江苏南京210004

出　　处：《中国医药导报》2020年第36期110-113,共4页China Medical Herald

基　　金：国家自然科学基金资助项目(81501271)。

摘　　要：目的开展重度子痫前期患者药学服务,促进硫酸镁用药规范化,评价监护效果。方法收集2016年7月—2017年6月南京医科大学附属妇产医院收治的重度子痫前期患者病历资料纳入对照组(178例)。2017年7月—12月制订药学监护计划,2018年1月—12月入院的重度子痫前期患者纳入干预组(185例),记录药学干预结果。比较两组产前、产后及妊娠32周内分娩患者硫酸镁使用情况,治疗方案及妊娠结局。结果干预组硫酸镁总体使用人数、产前硫酸镁使用人数、产后硫酸镁使用人数、产前及产后硫酸镁同时使用人数均多于对照组,差异有统计学意义(P<0.05)。两组产前硫酸镁维持日剂量及维持用药时间、产后硫酸镁用药时间、产前及产后用药总时间、镁离子监测例数及水平比较,差异均无统计学意义(P>0.05)。干预组产前硫酸镁使用人数多于对照组,差异有统计学意义(P<0.05);两组硫酸镁使用人数比较,差异无统计学意义(P>0.05)。两组子痫发生人数、分娩方式、终止妊娠时间、所有胎儿平均体重比较,差异均无统计学意义(P>0.05);干预组延长妊娠时间长于对照组,差异有统计学意义(P<0.05)。结论硫酸镁预防重度子痫前期患者子痫发作临床使用欠缺,通过开展药学服务,促进临床用药更加合理、规范,同时改善妊娠结局。Objective To evaluate the pharmacy monitoring outcomes of patients with severe pre-eclampsia by promoting the standard use of magnesium sulfate after pharmaceutical care.Methods From July 2016 to June 2017,the medical records of patients with severe pre-eclampsia admitted to Women’s Hospital of Nanjing Medical University were collected and as control group(178 cases).Pharmaceutical care plan was formulated from July to December 2017.Patients with severe pre-eclampsia admitted from January to December 2018 were selected as intervention group(185 cases).The results of pharmaceutical intervention were recorded.The use of magnesium sulfate before pregnancy,after pregnancy and within 32 weeks of pregnancy,the treatment schedule and pregnancy outcomes were compared between the two groups.Results The number of overall utilization of magnesium sulfate,the utilization of prenatal magnesium sulfate,the utilization of postpartum magnesium sulfate,the utilization of both prenatal and postpartum magnesium sulfate in intervention group were larger than those in control group(P<0.05).There were no significant differences in the daily dose and duration of magnesium sulfate maintenance,postpartum magnesium sulfate administration time,total prenatal and postpartum medication time,and the number and level of magnesium ion monitoring between two groups(P>0.05).The number of utilization of magnesium sulfate in intervention group was larger than that in control group(P<0.05).There was no significant difference in the incidence of utilization of magnesium sulfate between two groups(P>0.05).There were no significant differences in the eclampsia,mode of delivery,time of termination of pregnancy and average weight of all fetuses between two groups(P>0.05).The duration of pregnancy in intervention group was longer than that in control group(P<0.05).Conclusion Magnesium sulfate in preventing eclampsia in patients with severe pre-eclampsia is still lack of clinical use.By implementing pharmaceutical care measures,the standard use of magnes

关 键 词：重度子痫前期 子痫预防 硫酸镁 用药评价 药学监护 

分 类 号：R714.245[医药卫生—妇产科学]