早发型子痫前期患者血清铁蛋白和CysC水平与妊娠结局关系  

The correlation between serum ferritin and CysC levels of women with early-onset preeclampsia and their pregnancy outcomes

作　　者：邹飞平 游媛[1] 陈岚[1] ZOU Feiping;YOU Yuan;CHEN Lan(West Hospital of Union Hospital affiliated to Tongji Medical College of Huazhong University of Science and Technology,Wuhan, Hubei Province, 430056)

机构地区：[1]华中科技大学同济医学院附属协和医院西院,武汉430056

出　　处：《中国计划生育学杂志》2020年第12期2017-2020,共4页Chinese Journal of Family Planning

摘　　要：目的:探讨早发型子痫前期患者血清铁蛋白(SF)和胱抑素C(CysC)水平与妊娠结局的相关性。方法:分别选择80例早发型子痫前期孕妇(观察组)和60例正常孕妇(对照组),分别检测血清SF、CysC水平,分析观察组中不同病情(轻度和重度)、妊娠结局者SF、CysC差异。logistic回归分析SF、CysC与早发型子痫前期患者妊娠结局关系。结果:血清SF、Cysc水平观察组高于对照组,且重度患者高于轻度患者,不良妊娠结局者高于妊娠结局良好者(P>0.05)。Kaplan-Meier分析,高水平SF孕妇不良妊娠结局发生率高于低水平SF孕妇(χ2=6.362,P=0.012),高Cysc水平孕妇高于低Cysc水平孕妇(χ2=6.687,P=0.010);Cox风险回归分析,SF、CysC与早发型子痫前期患者不良妊娠结局独立相关(β=2.651、1.695,均P=0.000)。结论:血清SF、Cysc水平与早发型子痫前期患者妊娠结局相关,提示高水平SF、Cysc对不良妊娠结局可能有预测价值。Objective:To investigate the correlation between serum ferritin(SF)and cystatin C(CysC)levels of women with early-onset preeclampsia and their pregnancy outcomes.Methods:80 pregnant women with early-onset preeclampsia were included in observation group and 60 normal pregnant women were included in control group.Serum SF and CysC levels of women in the two groups were detected.In the observation group,the difference of SF and CysC levels of women with different degree of preeclampsia,and with different pregnancy outcomes were analyzed.Logistic regression was used to analyze the relationship between the levels of SF and CysC of women with early-onset preeclampsia and their pregnancy outcomes.Results:The serum SF and CysC levels of women in the observation group were significant higher than those of women in the control group.In the observation group,the serum SF and CysC levels of women with severe preeclampsia were significant higher than those of women with mild preeclampsia,and the serum SF and CysC levels of women with normal pregnancy outcomes were significant higher than those of women with adverse pregnancy outcomes.Kaplan-Meier analysis showed that the incidence of adverse pregnancy outcomes of women with high SF level was significant higher than that of women with low SF level(χ2=6.362,P=0.012),and the incidence of adverse pregnancy outcomes of women with high Cysc level was significant higher than that of women with low Cysc level(χ2=6.687,P=0.010).Cox risk regression analysis of SF level(β=2.651,P=0.000)and Scr level(β=1.695,P=0.000)independently associated with adverse pregnancy outcomes of women with early-onset preeclampsia.Conclusion:Serum SF and Cysc levels are correlated with pregnancy outcomes of women with early-onset preeclampsia,which means that high levels of SF and Cysc maybe predictive value of adverse pregnancy outcomes.

关 键 词：早发型子痫前期 血清铁蛋白 胱抑素C 妊娠结局 预测 

分 类 号：R71[医药卫生—妇产科学]