APOE基因启动子-491多态性与VD患病人群病情进展程度及BPSD的关系分析  

Relationship between ApoE gene promoter-491 polymorphism and disease progression and BPSD in vascular dementia patients

作　　者：白璇[1] 李新辉[1] 高春雪 BAI Xuan;LI Xinhui;DAO Chunxue(Department of Neurology,Liaoning Provincial People's Hospital,Shenyang 110016,China)

机构地区：[1]辽宁省人民医院神经内科,辽宁沈阳110016

出　　处：《中国急救复苏与灾害医学杂志》2020年第12期1436-1438,1449,共4页China Journal of Emergency Resuscitation and Disaster Medicine

基　　金：辽宁省科学技术厅项目(编号:2019-ZD-0408)。

摘　　要：目的研究APOE基因启动子-491多态性与VD患病人群病情进展程度及BPSD的关系。方法本研究采用2017年1月—2019年12月辽宁省人民医院诊断的血管性痴呆患者160例作为研究对象,据血管性痴呆诊断标准中的精神行为症状分析,BPSD患者以及非BPSD患者各80例,分别对两组患者的APOE基因启动子-491的基因多态性以及基因频率进行比较,分析不同基因型别患者的BPSD发生率的差异。同时,分析APOE基因启动子-491多态性与VD患病人群病情进展程度及BPSD的相关性。结果两组患者的APOE基因启动子-491基因型之间的差异存在统计学意义(χ^2=15.223,P<0.05),BPSD组患者的APOE基因启动子-491基因型ε2/ε3显著低于非BPSD组,ε3/ε4、ε4/ε4基因型显著高于非BPSD组。ε2、ε4基因型显著低于非BPSD组(χ^2=6.771,P<0.05),ε3基因型显著高于非BPSD组(P<0.05);BPSD组患者的APOEε3(+)的BPSD比例显著高于非BPSD组(χ^2=4.312,P<0.05)。患者的APOEε3(+)与BPSD呈现显著负相关(r=0.339,P<0.05)。结论APOE基因启动子-491多态性与血管性痴呆患者的发病率以及BPSD显著相关,未来可作为血管性痴呆患者BPSD诊断以及早期干预的重要依据。Objective To study the relationship between ApoE gene promoter-491 polymorphism and disease progression and behavioral and psychological symptoms of dementia(BPSD)in vascular dementis(VD)patients.Methods:In this study,160 patients with vascular dementia diagnosed from January 2017 to December 2019 were selected as the research objects.According to the analysis of mental and behavioral symptoms in the diagnostic criteria of vascular dementia,80 patients with BPSD and 80 patients without BPSD were respectively compared in the gene polymorphism and gene frequency of ApoE gene promoter-491 in the two groups,and the difference in the incidence of BPSD in patients with different gene types was analyzed Different.Results The difference of APOE gene promoter-491 genotype between the two groups was statistically significant(χ^2=15.223,P<0.05).The APOE gene promoter-491 genotypeε2/ε3 in BPSD group was significantly lower than that in non-BPSD group,and theε3/ε4 andε4/ε4 genotypes were significantly higher than that in non-BPSD group.The genotypes ofε2 andε4 were significantly lower than those of non-BPSD group(χ^2=6.771,P<0.05),and the genotypes ofε3 were significantly higher than those of non-BPSD group(P<0.05);the proportion of BPSD of APOEε3(+)in BPSD group was significantly higher than that in non-BPSD group(χ^2=4.312,P<0.05).There was a significant negative correlation between APOEε3(+)and BPSD(r=0.339,P<0.05).Conclusion:The-491 polymorphism of APOE gene is significantly associated with the incidence rate and BPSD of patients with vascular dementia.It is an important basis for BPSD diagnosis and early intervention in patients with vascular dementia.

关 键 词：APOE基因启动子-491多态性 血管性痴呆 载脂蛋白 疾病诊断 

分 类 号：R631[医药卫生—外科学]