糖痹康治疗糖尿病痛性神经病变40例  

Tangbikang in Treating 40 Cases of Diabetic Painful Neuropathy

作　　者：贾典荣 魏平 魏晓燕 翟云云 JIA Dianrong;WEI Ping;WEI Xiaoyan;DI Yunyun(Taizhou City Jiangyan TCM Hospital,Taizhou 225500,China)

机构地区：[1]泰州市姜堰中医院,江苏泰州225500

出　　处：《西部中医药》2020年第10期108-110,共3页Western Journal of Traditional Chinese Medicine

基　　金：泰州市姜堰区科技计划项目(300206)。

摘　　要：目的:观察糖痹康治疗糖尿病痛性神经病变(diabetic painful neuropathy,DPN)的临床疗效。方法:将80例患者随机分为两组,每组40例。两组给予常规基础治疗,对照组加服加巴喷丁。观察组在对照组治疗基础上口服糖痹康。两组均于连续治疗8周后评价临床疗效,比较治疗前后两组疼痛数字分级法(numerical rating scale,NRS)评分及血浆β-内啡呔(β-endorphin,β-EP)、血糖、血脂的变化情况。结果:总有效率观察组为92.50%(37/40),对照组为75.00%(30/40),临床疗效观察组优于对照组(P<0.05)。NRS评分及β-EP水平治疗后相同时间点两组比较,差异有统计学意义(P<0.05)。神经传导速度治疗后两组比较,差异有统计学意义(P<0.05)。血糖及血脂水平治疗前后两组组间比较,差异均无统计学意义(P>0.05)。结论:糖痹康用于DPN患者可升高β-EP水平,提高神经传导速度,从而提高疗效,且不影响患者血糖血脂水平控制。Objective: To observe clinical effects of Tangbikang in the treatment of diabetic painful neuropathy(PDN). Methods: Eighty patients were randomized into two groups, 40 cases each group. Both groups accepted conventional basic therapy, and the control group took gabapentin. The observation group took Tangbikang orally based on the therapy the control group received. Both groups were treated for eight weeks consecutively to assess clinical effects, to compare NRS scores, the changes of β-EP, blood glucose and blood lipid before and after treating.Results: Total effective rate of the observation group was 92.50%(37/40), higher than 75.00%(30/40) of the control group, the observation group was superior to the control group in clinical effects(P<0.05). The difference showed statistical meaning in NRS scores and the levels of β-EP at the same time between both groups after treating(P<0.05). The difference had statistical meaning in nerve conduction velocity(NCV) between both groups after treating(P <0.05). The difference had no statistical meaning in the levels of blood glucose and blood lipid(P >0.05).Conclusion: Tangbikang could lift the levels of β-EP in DPN patients, raise NCV, therefore to improve clinical effects, and won′t affect the levels of blood glucose and blood lipid.

关 键 词：糖尿病痛性神经病变 糖痹康 临床疗效 疼痛数字分级法 血浆β-内啡呔 

分 类 号：R587.1[医药卫生—内分泌]