S-型色氨酸生物合成系统的稳态优化  

Steady-state optimization of S-type tryptophan biosynthesis system

作　　者：逯赫 徐恭贤[1] LU He;XU Gongxian(College of Mathematical Sciences,Bohai University,Jinzhou 121013,China)

机构地区：[1]渤海大学数学科学学院,辽宁锦州121013

出　　处：《渤海大学学报（自然科学版）》2020年第2期156-159,共4页Journal of Bohai University:Natural Science Edition

基　　金：国家自然科学基金项目(No:11101051);辽宁省自然科学基金项目(No:20180550839);辽宁省教育厅科学研究项目(No:LJ2020015)。

摘　　要：研究了S-型色氨酸生物合成系统的稳态优化问题.针对该问题,首先给出S-型色氨酸生物合成系统的数学模型,然后构建S-型色氨酸生物合成系统的稳态优化模型.为了求解前面构建的稳态优化问题,基于Hurwitz准则将所构建的稳态优化问题转化为新的非线性规划问题.通过计算转化后的非线性规划问题,获得了S-型色氨酸生物合成系统稳态优化问题的最优解.结果表明,与基本稳态时的色氨酸产率1.310202相比,本文获得了更高的色氨酸产率5.728457.This paper is concerned with the steady-state optimization of S-type tryptophan biosynthesis system.Firstly,a mathematical model of S-type tryptophan biosynthesis system is given.Then a steady-state optimization model of S-type tryptophan biosynthesis system is constructed.To solve the constructed steady-state optimization problem,it is transformed to a new nonlinear programming by using the Hurwitz criterion.Solving the new problem,the optimal solution for the steady-state optimization of S-type tryptophan biosynthesis system is attained.The attained rate of tryptophan production is 5.728457,which is higher than the production rate 1.310202 at the basal steady-state.

关 键 词：色氨酸生物合成 S-型系统 稳态优化 非线性规划 

分 类 号：O22[理学—运筹学与控制论] O29[理学—数学]