寨卡病毒及其与宿主蛋白相互作用研究进展  

Research Progress on Zika Virus and Its Interactions with Host Proteins

作　　者：任琴 杜寿文 吕孔鹏 张星艳 戴少波 李体远[1] 田明尧 吴诗品[1] 李昌 REN Qin;DU Shouwen;LYU Kongpeng;ZHANG Xingyan;DAI Shaobo;LI Tiyuan;TIAN Mingyao;WU Shipin;LI Chang(Department of Infectious Diseases,The 2nd Clinical Medical College(Shenzhen People's Hospital)of Jinan University,Guangdong Shenzhen 518020,China;Research Unit of Key Technologies for Prevention and Control of Virus Zoonoses,Chinese Academy of Medical Sciences,Institute of Military Veterinary Medicine,Academy of Military Medical Sciences,Academy of Military Sciences,Jilin Changchun 130062,China)

机构地区：[1]暨南大学第二临床医学院(深圳市人民医院)感染内科,深圳518000 [2]军事科学院军事医学研究院军事兽医研究所中国医学科学院人兽共患病毒病防控关键技术研究创新单元,长春130062

出　　处：《病毒学报》2020年第6期1201-1207,共7页Chinese Journal of Virology

基　　金：国家自然科学基金(项目号:31702210),题目:不同种属的宿主限制因子IFITM3抗流感病毒共有模式研究;兽医生物技术国家重点实验室开放课题(项目号:SKLVBF201914),题目:甲型流感病毒HA蛋白与IFITM3间的相互作用机制。

摘　　要：寨卡病毒(Zika virus,ZIKV)作为一种新出现的蚊媒病原体,与成人格林-巴利综合征(Guillain–Barresyndrome,GBS)、新生儿小头畸形以及神经系统缺陷等疾病有关。2016年世界卫生组织将寨卡疫情列为国际关注的公共卫生突发事件,近年来关于ZIKV病原学、流行病学、感染与致病、抗病毒免疫应答、疫苗与药物的研究越来越多,为有效防控该病提供了理论依据和具体实践。本文就ZIKV蛋白组成及相应功能、感染周期、ZIKV受体及ZIKV-宿主相互作用等的最新研究进展进行综述,旨在正确认识和深入理解ZIKV致病与机体抗病相关机制,为设计有效的预防或治疗疫苗或药物提供参考资料。Zika virus(ZIKV)is an emerging mosquito-borne pathogen,which is associated with Guillain–Barrésyndrome in adults and microcephaly and other neurological defects in newborns.The world health organization listed ZIKV infection to be a public health emergency of international concern in 2016.In recent years,increasing numbers of studies have been conducted on the etiology,epidemiology,infection pathways and pathogenesis of the ZIKV,as well as the antiviral immune response,vaccine development and potential drugs.Such studies have provided a theoretical basis and practice guidelines for the effective prevention and control of ZIKV infection.Here,we detail the latest research progress on the protein structure and function,infection cycle,receptors of the ZIKV as well as ZIKV-host interactions.In this way,we provide reference material for the design of efficacious vaccines or drugs.

关 键 词：寨卡病毒(ZIKV) 蛋白组成及功能 病毒受体 病毒-宿主相互作用 

分 类 号：R373.3[医药卫生—病原生物学]