乙型流感病毒致病力相关分子标记研究进展  

Advances in Molecular Markers Related to the Pathogenicity of Influenza B Viruses

作　　者：周丽娟 朱闻斐[2] 舒跃龙 ZHOU Lijuan;ZHU Wenfei;SHU Yuelong(School of Public Health(Shenzhen),Sun Yat-sen University,Guangzhou 510006,China;National Institute for Viral Disease Control and Prevention,Chinese Center for Disease Control and Prevention,Beijing 102206,China)

机构地区：[1]中山大学公共卫生学院(深圳),广州510006 [2]中国疾病预防控制中心病毒病预防控制所,北京102206

出　　处：《病毒学报》2020年第6期1208-1212,共5页Chinese Journal of Virology

基　　金：“十三五”重大专项(项目号:2017ZX10104001002002),题目:基于宏基因组学的病毒网络化监测和溯源技术体系研究;国自然项目(项目号:81971941),题目:乙型流感病毒致病分子机制研究。

摘　　要：乙型流感对人类公共卫生安全的威胁非常严重,全球每年流感相关疾病负担的三分之一由乙型流感导致。了解乙型流感病毒致病力相关关键分子标记,有助于更高效、准确地评估乙型流感病毒致病力,预测病毒的流行潜能。本文对乙型流感病毒致病力相关分子标记的研究进展进行综述,旨在为乙型流感病毒的监测、防控及新型疫苗与抗病毒药物的研发提供理论依据。Influenza B viruses(IBVs)are human respiratory viruses.On average,they cause one-third of the influenza-related disease burden each year worldwide,which presents a serious threat to public health.Understanding the molecular markers related to IBV pathogenicity will aid more effective and accurate assessment of the pathogenicity and help to predict the prevalence of IBVs.In this review,we summarize current understanding about the molecular markers that affect the pathogenicity and transmission of IBVs.Continued investigation of the molecular mechanism of IBV pathogenicity should facilitate development of novel approaches to the treatment and prevention of IBVs.

关 键 词：乙型流感病毒 致病力 分子标记 

分 类 号：R373.1[医药卫生—病原生物学]