大血藤化学成分研究  

Chemical constituents isolated from Sargentodoxa cuneate

作　　者：张文 周爽 孙成鹏 邓冬 车金花 范甜 马骁驰[3] 方邦江[1] ZHANG Wen;ZHOU Shuang;SUN Chengpeng;DENG Dong;CHE Jinhua;FAN Tian;MA Xiaochi;FANG Bangjiang(Department of Emergency,Umghua Hospital,Shanghai University of Traditional Chinese Medicine,Shanghai 200032,China;College of Acumox and Tuina,Shanghai University of Traditional Chinese Medicine,Shanghai 201203,China;College of Pharmacy,Dalian Medical University.Dalian 116044,Liaoning,China;Medical Department of Hubei Minzu University,Enshi 445000,Hubei,China)

机构地区：[1]上海中医药大学附属龙华医院急诊科,上海200032 [2]上海中医药大学针灸推拿学院,上海200032 [3]大连医科大学药学院,辽宁大连116044 [4]湖北民族大学医学部,湖北恩施445000

出　　处：《上海中医药杂志》2020年第11期85-88,共4页Shanghai Journal of Traditional Chinese Medicine

基　　金：国家重点研发计划项目(2018YFC1705900);上海科技创新行动计划项目(18401971600);上海市科委科研计划项目(19401933300)。

摘　　要：目的研究大血藤Sargentodoxa cuneata(Oliv.)Rehd.et Wils.茎部化学成分。方法采用系统溶剂法对大血藤根茎进行提取,并采用硅胶柱、ODS柱和制备型HPLC等色谱技术对其进行分离纯化,根据理化性质及核磁共振波谱数据鉴定化合物的结构。结果从大血藤的95%乙醇提取物中分离得到10个化合物,分别鉴定为省沽油香堇苷D(staphylionoside D,化合物1)、4-羟基-1-(2-硝乙基)苯4-O-(6′-O-β-D-木糖基)-β-D-葡萄糖苷[4-hydroxy-1-(2-nitroethyl)benzene 4-O-(6′-O-β-D-xylopyranosyl)-β-D-glucopyranoside,化合物2]、香草醇4-O-β-D-葡萄糖苷(vanillyl alcohol-4-O-β-D-glucopyranoside,化合物3)、3,4,5-三甲氧基苯基-β-D-葡萄糖苷(3,4,5-trimethoxyphenyl-β-D-glucopyranoside,化合物4)、异它乔糖苷(isotachioside,化合物5)、4-羟基-3,5-二甲氧基-苯酚(4-hydroxy-3,5-dimethoxy-phenol,化合物6)、2-(2′-烯丙基)2,3-苯并二氢呋喃-5-甲酸(dimethyl 2,3′-dimethoxyosoate,化合物7)、尿苷(uridine,化合物8)、丁香醛(syringaldehyde,化合物9)和5-羟基-3-甲氧基-2-(3′-甲氧基-2-甲酸酯基)-5-甲基苯基-苯甲酸甲酯(fomannoxin acid,化合物10)。结论所有化合物均为首次从大血藤属植物中分离得到。Objective To investigate the chemical constitutes from the stems of Sargentodoxa cuneata. Methods Compounds were extracted by the method of system solvent,and isolated and purified by a combination of various chromatographic techniques,including silica gel column,ODS column,and preparative HPLC methods.Their structures were elucidated on the basis of their physiochemical property and NMR spectra. Results Ten compounds were obtained from 95% ethanol extract of the stems of Sargentodoxa cuneata and identified as staphylionoside D,4-hydroxy-1-(2-nitroethyl)benzene 4-O-(6′-O-β-D-xylopyranosyl)-β-D-glucopyranoside,vanillyl alcohol-4-O-β-D-glucopyranoside,3,4,5-trimethoxyphenyl-β-D-glucopyranoside,isotachioside,4-hydroxy-3,5-dimethoxy-phenol,dimethyl 2,3′-dimethoxyosoate,uridine,syringaldehyde and fomannoxin acid, respectively. Conclusion All compounds are isolated from the genus Sargentodoxa for the first time.

关 键 词：大血藤 省沽油香堇苷D 4-羟基-1-(2-硝乙基)苯4-O-(6′-O-β-D-木糖基)-β-D-葡萄糖苷 香草醇4-O-β-D-葡萄糖苷 化学成分 

分 类 号：R284.1[医药卫生—中药学]