妊高症患者联合检测血清ACA、抗β2GPⅠ及脂代谢水平的临床意义  

Clinical significance of serum ACA,antiβ2GPⅠand lipid metabolism in patients with PIH

作　　者：李介岩[1] 李晓丽[2] LI Jie-yan;LI Xiao-li(Department of Obstetrics,Beijing Obstetrics and Gynecology Hospital Affiliated to Capital Medical University,Beijing 100026,China)

机构地区：[1]首都医科大学附属北京妇产医院产科,北京100026 [2]吉林大学中日联谊医院药学部

出　　处：《中国实验诊断学》2020年第12期1974-1977,共4页Chinese Journal of Laboratory Diagnosis

基　　金：首都医科大学附属北京妇产医院中青年学科骨干培养专项(fcyy801412)。

摘　　要：目的通过联合检测血清抗心磷脂抗体(ACA)、抗β2糖蛋白Ⅰ抗体(抗β2GPⅠ)及脂代谢(TC、TG、LDL、HDL、ApoA1和ApoB)的水平,探讨其表达水平对不同发病程度妊高症结局的影响。方法将我院产科收治并诊断为妊娠期高血压的孕妇200例作为实验组,依据发病程度又分为轻度子痫前期组70例、重度子痫前期组70例和子痫组60例;同期住院分娩的正常孕妇80例作为对照组。采用Epoch酶标仪和HITACHI全自动生化分析仪检测以上4组受试对象的血清学及脂代谢指标,评估4组受试者血清ACA、抗β2GPⅠ及脂代谢TC、TG、LDL、HDL、ApoA1和ApoB的水平对不同发病程度妊高症结局的影响。结果①与对照组比较,实验组血清ACA、抗β2GPⅠ及脂代谢TC、TG、LDL、ApoA1和ApoB的水平明显升高,且随发病严重程度呈升高趋势,各组差异显著具有统计学意义(P<0.05);实验组脂代谢HDL明显降低,且随发病严重程度呈下降趋势,各组差异显著具有统计学意义(P<0.05)。②与对照组比较,实验组妊娠结局指标胎儿生长受限、早产、围生儿死亡、胎盘早剥及死胎发生率明显增加,且随发病严重程度呈升高趋势,各组差异显著具有统计学意义(P<0.05)。结论孕妇血清中ACA、抗β2GPⅠ及脂代谢TC、TG、LDL、HDL、ApoA1和ApoB,可能参与了妊娠高血压病变的发生发展过程,因此早期联合检测上述指标对明确患者病情、及时采取临床干预措施及改善预后具有重要的临床应用价值。Objective The levels of serum anticardiolipin antibody(ACA),antiβ2 glycoproteinⅠ(antiβ2 GPⅠ)and lipid metabolism(TC,TG,LDL,HDL,ApoA1 and ApoB)were measured to explore the effect of their expression levels on the outcome of different degrees of PIH.Methods From January 2018 to November 2019,200 pregnant women admitted to our hospital in obstetrics and diagnosed as gestational hypertension were taken as the experimental group,which was divided into 70 cases of mild pre eclampsia group,70 cases of severe pre eclampsia group and 60 cases of eclampsia group according to the degree of incidence;80 cases of normal pregnant women in hospital during the same period were taken as the control group.The serum and lipid metabolism indexes of the above four groups were detected by epoch and HITACHI automatic biochemical analyzer,to evaluate the effects of serum ACA,antiβ2 GPⅠ,TC,TG,LDL,HDL,ApoA1 and ApoB on the outcome of PIH in different degrees.Results①Compared with the control group,the levels of serum ACA,antiβ2 GPⅠ,lipid metabolism TC,TG,LDL,ApoA1 and ApoB in the experimental group were significantly higher,and the difference was statistically significant(P<0.05);the HDL of lipid metabolism in the experimental group was significantly lower,and the difference was statistically significant(P<0.05).②Compared with the control group,the incidence of fetal growth restriction,premature delivery,perinatal death,placental abruption and stillbirth increased significantly in the experimental group,and the difference was statistically significant(P<0.05).Conclusion ACA,antiβ2 GPⅠ,TC,TG,LDL,HDL,ApoA1 and ApoB in serum of pregnant women may be involved in the occurrence and development of pregnancy induced hypertension.Therefore,early combined detection of the above indexes is of great clinical value in clarifying patients’condition,taking timely clinical intervention measures and improving prognosis.

关 键 词：妊娠高血压 子痫 抗心磷脂抗体 抗β2糖蛋白Ⅰ抗体 脂代谢 

分 类 号：R714.2[医药卫生—妇产科学]