比索洛尔治疗冠心病对LVESD、LVEF水平的影响  

Effect of bisoprolol on the level of LVESD and LVEF in patients with coronary heart disease

作　　者：汤展 何赣维 韦广 魏芝宝[1] TANG Zhan;HE Gan-wei;WEI Guang(Department of Cardiovascular Medicine,Gaozhou People’s Hospital,Gaozhou 525200,China)

机构地区：[1]高州市人民医院(心血管内科一区),525200

出　　处：《中国实用医药》2020年第35期4-7,共4页China Practical Medicine

摘　　要：目的探究老年冠心病患者采用比索洛尔治疗后对左室收缩末期内径(LVESD)、左室射血分数(LVEF)水平的影响。方法 120例老年冠心病患者作为研究对象,以治疗方案不同分为参照组和观察组,每组60例。参照组行阿托伐他汀治疗,观察组行比索洛尔+阿托伐他汀治疗。比较两组患者心功能指标水平、炎症因子[肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)、超敏C反应蛋白(hs-CRP)]水平、血清血管性假血友病因子(vWF)和血管内皮细胞生长因子(VEGF)水平。结果治疗前,两组患者LVESD、LVEF、LVEDD、TNF-α、IL-6、hs-CRP及血清vWF、VEGF水平比较差异无统计学意义(P>0.05)。治疗后,两组患者LVESD、LVEF、LVEDD水平均明显优于治疗前,且观察组患者LVESD(35.48±1.52)mm、LVEF(54.74±1.49)%、LVEDD(47.65±1.15)mm均明显优于参照组的(37.48±2.12)mm、(48.58±2.14)%、(53.41±2.21)mm,差异具有统计学意义(P<0.05)。治疗后,两组患者TNF-α、IL-6、hs-CRP水平均低于治疗前,且观察组患者TNF-α(5.23±1.02)mg/L、IL-6(12.41±2.11)ng/L、hs-CRP(3.01±0.36)mg/L均低于参照组的(8.75±1.12)mg/L、(18.56±2.54)ng/L、(4.78±0.55)mg/L,差异具有统计学意义(P<0.05)。治疗后,两组患者血清vWF、VEGF水平均低于治疗前,且观察组患者血清vWF(27.41±0.62)ng/L、VEGF(321.58±2.32)pmol/L均低于参照组的(31.12±0.87)ng/L、(572.14±3.24)pmol/L,差异具有统计学意义(P<0.05)。结论老年冠心病患者经比索洛尔治疗后,患者心功能得到改善,血清vWF、VEGF水平得以降低,炎症反应改善,具有较高的治疗价值。Objective To investigate the effect of bisoprolol on the level of left ventricular end systolic diameter(LVESD)and left ventricular ejection fraction(LVEF)in patients with coronary heart disease.Methods A total of 120 elderly patients with coronary heart disease as study subjects were divided into control group and observation group according to different treatment regimens,with 60 cases in each group.The control group was treated with atorvastatin,and the observation group was treated with bisoprolol and atorvastatin.The cardiac indicators,inflammatory factors[tumor necrosis factor-α(TNF-α),interleukin-6(IL-6),high-sensitivity C-reactive protein(hs-CRP)]and von Willebrand factor(VWF)and vascular endothelial growth factor(VEGF)were compared between the two groups.Results Before treatment,there was no statistically significant difference in LVESD,LVEF,LVEDD,TNF-α,IL-6,hs-CRP and vWF,VEGF between the two groups(P>0.05).After treatment,LVESD,LVEF and LVEDD of the two groups were obviously better than those before treatment,and LVESD(35.48±1.52)mm,LVEF(54.74±1.49)%and LVEDD(47.65±1.15)mm of the observation group were obviously better than(37.48±2.12)mm,(48.58±2.14)%and(53.41±2.21)mm of the control group,and the difference was statistically significant(P<0.05).After treatment,TNF-α,IL-6 and hs-CRP of the two groups were lower than those before treatment,and TNF-α(5.23±1.02)mg/L,IL-6(12.41±2.11)ng/L and hs-CRP(3.01±0.36)mg/L of the observation group were all lower than(8.75±1.12)mg/L,(18.56±2.54)ng/L and(4.78±0.55)mg/L of the control group,and the difference was statistically significant(P<0.05).After treatment,the serum vWF and VEGF of the two groups were lower than those before treatment,and vWF(27.41±0.62)ng/L and VEGF(321.58±2.32)pmol/L of the observation group were lower than(31.12±0.87)ng/L and(572.14±3.24)pmol/L of the control group,and the difference was statistically significant(P<0.05).Conclusion After treatment with bisoprolol,the cardiac function of the elderly patients with coronary he

关 键 词：比索洛尔 冠心病 左室收缩末期内径 左室射血分数 

分 类 号：R541.4[医药卫生—心血管疾病]