塞来昔布对人工全膝关节置换术后血压的影响  

Effect of celecoxib on blood pressure after total knee arthroplasty

作　　者：张泳照 王俊生 赵东风 尹健石 武旭阳 闫寒 ZHANG Yong-zhao;WANG Jun-sheng;ZHAO Dong-feng(Department of Orthopaedics,967th Hospital of the Joint Logistics Support Force of the People's Liberation Army,Dalian 116000,China)

机构地区：[1]解放军联勤保障部队第967医院骨科,116000

出　　处：《中国实用医药》2020年第34期115-117,共3页China Practical Medicine

摘　　要：目的探讨塞来昔布对人工全膝关节置换(TKA)患者术后血压的影响。方法 90例采用人工膝关节置换治疗的膝关节骨性关节炎患者,根据术后用药不同分为塞来昔布组、帕瑞昔布组、对照组。各30例。塞来昔布组术后加服塞来昔布胶囊、帕瑞昔布组术后当晚给予帕瑞昔布、对照组采取常规治疗。观察比较三组不良反应发生情况,术前及术后5 d内的收缩压情况。结果塞来昔布组患者术前以及术后第1、2、3、4、5天的收缩压分别为(110.43±11.07)、(105.68±9.45)、(105.75±12.70)、(111.96±10.53)、(103.22±14.11)、(110.59±8.26)mm Hg(1 mm Hg=0.133 kPa),帕瑞昔布组患者术前以及术后第1、2、3、4、5天的收缩压分别为(109.28±11.45)、(109.23±6.37)、(111.18±10.53)、(110.57±9.48)、(109.41±9.01)、(111.46±10.52)mm Hg,对照组患者术前以及术后第1、2、3、4、5天的收缩压分别为(107.29±17.53)、(77.82±10.12)、(87.25±7.42)、(95.43±21.07)、(100.69±9.47)、(101.41±11.05)mm Hg。塞来昔布组、帕瑞昔布组术后第1、2、3、4、5天的收缩压与本组术前比较,差异均无统计学意义(P>0.05)。塞来昔布组、帕瑞昔布组术后第1、2、3、4、5天的收缩压组间比较,差异均无统计学意义(P>0.05)。对照组患者术后第1、2、3天收缩压均低于术前,差异均具有统计学意义(P<0.05);术后第4、5天与术前比较,差异均无统计学意义(P>0.05)。塞来昔布组和帕瑞昔布组术后第1、2、3天收缩压均高于对照组患者,差异均具有统计学意义(P<0.05)。三组术后第4、5天收缩压比较,差异均无统计学意义(P>0.05)。结论 TKA患者术后应用塞来昔布或帕瑞昔布都能较好地维持患者血压,减少并发症的发生,但塞来昔布仅需口服,患者的依从性更好,建议临床推广应用。Objective To discuss the effect of celecoxib on blood pressure of patients after total knee arthroplasty(TKA). Methods A total of 90 patients with knee osteoarthritis treated with total knee arthroplasty were divided into celecoxib group, parecoxib group and control group according to different postoperative medications, with 30 cases in each group. Celecoxib group received celecoxib capsule after operation, parecoxib group received parecoxib on the night after operation, and the control group received routine treatment.The occurrence of adverse reactions, systolic blood pressure before and 5 d after operation were observed and compared among the three groups. Results The systolic blood pressure before operation and 1, 2, 3, 4, 5 days after operation of celecoxib group were(110.43±11.07),(105.68±9.45),(105.75±12.70),(111.96±10.53),(103.22±14.11) and(110.59±8.26) mm Hg(1 mm Hg=0.133 kPa), which were(109.28±11.45),(109.23±6.37),(111.18±10.53),(110.57±9.48),(109.41±9.01) and(111.46±10.52) mm Hg of parecoxib group, and(107.29±17.53),(77.82±10.12),(87.25±7.42),(95.43±21.07),(100.69±9.47) and(101.41±11.05) mm Hg of the control group. There was no statistically significant difference in systolic blood pressure of celecoxib group and parecoxib group 1, 2, 3, 4 and 5 days after operation compared with those before operation(P>0.05). There was no statistically significant difference in systolic blood pressure between celecoxib group and parecoxib group 1, 2, 3, 4 and 5 days after operation(P>0.05). The systolic blood pressure 1, 2 and 3 day after operation of the control group was lower than that before operation, and the difference was statistically significant(P<0.05);there was no statistically significant difference the 4 and 5 days after operation compared with before operation(P>0.05). The systolic blood pressure 1, 2 and 3 day after operation of celecoxib group and parecoxib group were higher than those of the control group, and the difference was statistically significant(P<0.05). There was no stat

关 键 词：人工膝关节置换 血压 塞来昔布 帕瑞昔布 

分 类 号：R687.4[医药卫生—骨科学]