寄生虫感染与宿主细胞自噬相互作用研究进展  

Progress of researches on the interaction between parasitic infections and host cell autophagy

作　　者：吴阳 任红玲 徐珊珊 高媛[1] 崔昱[1] WU Yang;REN Hong-Ling;XU Shan-Shan;GAO Yuan;CUI Yu(Department of Parasitology,Dalian Medical University,Dalian 116044,China)

机构地区：[1]大连医科大学寄生虫学教研室,大连116044

出　　处：《中国血吸虫病防治杂志》2020年第6期654-656,660,共4页Chinese Journal of Schistosomiasis Control

摘　　要：自噬是一种真核细胞特有的生命现象,是一种保守的细胞内降解系统。通常所说的自噬是通过双层膜包裹细胞质成分形成自噬体,随后与溶酶体融合,从而降解细胞自身物质的过程。自噬可以由饥饿诱导,也可以由包括寄生虫在内的各种病原体所诱导。当机体感染胞内寄生虫时,宿主细胞可以通过自噬清除寄生虫。然而,寄生虫也进化出自身防御机制,能够利用宿主细胞自噬促进自身发育生长。本文综述了目前国内外关于寄生虫感染与宿主细胞自噬相互影响的研究进展,深入探讨自噬作用对防治寄生虫感染和抗虫药物研发具有重要意义。Autophagy,a conserved intracellular degradation system,is a specific life phenomenon in eukaryocytes.Autophagy is widely accepted as a pathway that double⁃membrane autophagosomes envelop and sequester intracellular cytoplasmic compo⁃nents and then fuse with lysosomes to form autolysosomes,which degrade their contents to regenerate nutrients.Autophagy may be triggered by starvation and a diverse range of pathogens,including parasites.Following infection with intracellular parasites,host cells may eliminate parasites by autophagy.However,parasites may develop self⁃defense mechanisms,and promote the self⁃growth and⁃development by host cell autophagy.This review describes the advances in the interplay between parasitic infections and host cell autophagy.Understanding autophagy is of great significance for the management of parasitic infections and the de⁃velopment of antiparasitic drugs.

关 键 词：寄生虫 自噬 刚地弓形虫 疟原虫 布氏锥虫 利什曼原虫 

分 类 号：R38[医药卫生—医学寄生虫学]