妊娠期糖尿病患者血清雌激素α受体水平的检测及其临床意义  

Serum level and clinical significance of estrogen receptor α in gestational diabetes

作　　者：樊柳宜 陈捷[1] 曹玉英 黄国伟 FAN Liu-yi;CHEN Jie;CAO Yu-ying;HUANG Guo-wei(Department of Obstetrics,Affiliated Shunde Hospital,Jinan University,Foshan 528305,China)

机构地区：[1]广东省暨南大学附属顺德医院产科,广东佛山528305

出　　处：《广东医科大学学报》2020年第6期706-709,共4页Journal of Guangdong Medical University

基　　金：佛山市自筹经费类科技计划项目(No.2018AB002373)。

摘　　要：目的观察妊娠期糖尿病(GDM)患者血清雌激素α受体(ERα)水平变化及其临床意义。方法检测52例GDM孕妇(观察组)及52例正常孕妇(对照组)血清ERα水平、早期肾损伤指标(NGAL、Cys-C、β2-MG),分析ERα与早期肾损伤指标相关性及其对GDM诊断价值。结果观察组血清ERα水平和早期肾损伤指标均明显高于对照组(P<0.01),且二者呈显著正相关(P<0.01)。血清ERα诊断早期GDM的曲线下面积AUC值为0.908(95%CI 0.853~0.964,P<0.01),ERα高水平GDM患者妊娠不良事件高于ERα低水平者(P<0.05)。结果GDM患者血清ERα水平增高提示早期肾损伤及妊娠不良事件发生率增高,可能是GDM早期诊断指标。Objective To evaluate the serum level and clinical value of estrogen receptorα(ERα)in gestational diabetes mellitus(GDM).Methods Serum ERαlevel and early renal injury indexes(ERIIs)including neutrophil gelatinase-associated lipocalin,cystain-C,andβ2-microglobulin were detected in 52 GDM(observation group)and 52 normal pregnant women(control group).The correlation between ERαand ERIIs and diagnostic value of ERαon GDM were analyzed.Results Serum ERαlevel and ERIIs were higher in observation group than in control group(P<0.01),with a significant positive correlation between ERαand ERIIs(P<0.01).The area under the curve(AUC)of ERαfor early diagnosis of GDM was 0.908(95%CI 0.853-0.964,P<0.01).Adverse pregnancy events were more common in GDM patients with high ERαlevel than in those with low ERαlevel(P<0.05).Conclusion The increased serum ERαcontent may predict early renal injury and adverse pregnancy events in GDM patients and serve as an early diagnosis biomarker for GDM.

关 键 词：雌激素Α受体 妊娠期糖尿病 早期诊断 

分 类 号：R714[医药卫生—妇产科学]