新生儿GBS感染败血症患儿血乳酸和血清炎症指标水平及临床意义  

Levels and clinical significance of blood lactate and serum inflammatory biomarkers in neonates with GBS-induced sepsis

作　　者：范小萍 叶旭芳[2] 毛月燕[1] 苏畅[1] FAN Xiao-Ping;YE Xu-Fang;MAO Yue-Yan(Department of Neonatology,the First People’s Hospital of Yuhang District,Hangzhou,Zhejiang 311100,China;不详)

机构地区：[1]杭州市余杭区第一人民医院新生儿科,浙江杭州311100 [2]杭州市余杭区第一人民医院检验科,浙江杭州311100

出　　处：《中国妇幼保健》2020年第24期4764-4766,共3页Maternal and Child Health Care of China

摘　　要：目的分析新生儿B族链球菌(GBS)感染败血症患儿血乳酸、C-反应蛋白(CRP)、降钙素原(PCT)、白细胞介素-6(IL-6)水平及临床意义。方法选择2015年10月-2019年10月杭州市余杭区第一人民医院收治的106例感染新生儿为研究对象,根据病情分为GBS感染败血症组(56例)和局部感染组(50例)。另选取52例健康新生儿为对照组。检测3组血乳酸、CRP、PCT、IL-6水平,分析诊断GBS感染败血症的价值。结果3组新生儿入院时血乳酸、CRP、PCT和IL-6水平比较差异均有统计学意义(均P<0.05),GBS感染败血症组各项指标水平最高。GBS感染败血症患儿治疗前后血乳酸、CRP、PCT和IL-6水平比较差异均有统计学意义(均P<0.05)。血乳酸、CRP、PCT、IL-6单独检测时,CRP的AUC值最大,IL-6的AUC值最低。四者联合检测时AUC值接近于1,高于单独检测。结论血乳酸、CRP、PCT和IL-6水平检测对于GBS感染败血症新生儿的早期诊断具有重大的临床意义,CRP的诊断价值最高,IL-6的诊断价值最低,且4项指标联合的检测效果最好。Objective To analyze the levels and clinical significance of blood lactate,C-reactive protein(CRP),procalcitonin(PCT),and interleukin-6(IL-6)in neonates with group B streptococcus(GBS)-induced sepsis.Methods From October 2015 to October 2019,106 neonates with infection treated in the First People’s Hospital of Yuhang District were selected and divided into GBS-induced sepsis group(56 neonates)and(50 neonates),52 healthy neonates were selected as control group.The levels of blood lactate,CRP,PCT,and IL-6 in the three groups were detected,the value in diagnosis of GBS-induced sepsis was analyzed.Results At admission,there were statistically significant differences in the levels of blood lactate,CRP,PCT,and IL-6 among the three groups(P<0.05),the levels of blood lactate,CRP,PCT,and IL-6 were the highest in GBS-induced sepsis group.There were statistically significant differences in the levels of blood lactate,CRP,PCT,and IL-6 between before and after treatment in GBS-induced sepsis group(P<0.05).AUC value of CRP was the highest among the four indicators,AUC value of IL-6 was the lowest,AUC value of combined detection of the four indicators was nearly equal to 1,which was higher than those of single detection.Conclusion Detection of blood lactate,CRP,PCT,and IL-6 has great clinical significance in early diagnosis of GBS-induced sepsis in neonates,the diagnostic value of CRP is the highest,the diagnostic value of IL-6 is the lowest,the effect of combined detection of the four indicators is the best.

关 键 词：新生儿GBS感染败血症 血乳酸 C-反应蛋白 降钙素原 白细胞介素-6 

分 类 号：R722.1[医药卫生—儿科]