皮肤光老化机制及治疗制剂研究进展  

Research progress in the mechanisms and therapeutic agents of skin photoaging

作　　者：何丽 林雪霏[1] 陈慧[1] 隋长霖 李曼[1] 朱威[1] HE Li;LIN Xue-fei;CHEN Hui(Deparment of Dermatolog,Xinwu Hospital,Capital Medical Universiny,Beijing 100053,China)

机构地区：[1]首都医科大学宣武医院皮肤性病科,北京100053

出　　处：《实用皮肤病学杂志》2020年第5期293-296,共4页Journal of Practical Dermatology

基　　金：北京市自然科学基金项目(7172092)。

摘　　要：紫外线照射皮肤后,可通过MAPK、NF-κB、Nrf2/ARE及TGF-β/Smad等多条信号通路影响皮肤细胞的正常功能,发生皮肤光老化。当前已经发现许多植物及生物提取物可通过外用、口服或皮下注射等方法对光老化皮肤发挥一定保护作用。该文介绍了紫外线对皮肤的影响,并对光老化发生的主要信号通路和用于抗光老化的制剂进行综述。Ultraviolet irradiation can affect the normal function of skin cells and results in skin photoaging through multiple signaling pathways including MAPK, NF-κB, Nrf2/ARE and TGF-β/Smad. At present, it has been found that many plant and biological extracts can be used to protect the skin from photoaging by topical use, oral or subcutaneous injection, et al. This paper introduces the effects of Ultraviolet on the skin and reviews the main signaling pathways of photoaging and the agents for anti-photoaging.

关 键 词：光老化 信号通路 胶原蛋白 

分 类 号：R758.1[医药卫生—皮肤病学与性病学]