阿卡波糖、二甲双胍联合胰岛素类似物治疗2型糖尿病体型偏胖患者的短期疗效  

Short-term Efficacy of Acarbose,Metformin Combined with Insulin Analogues in the Treatment of Obese Patients with Type 2 Diabetes

作　　者：王刚 WANG Gang(Department of Internal Medicine,Funing County Hospital of Traditional Chinese Medicine,Funing,Jiangsu Province,224400 China)

机构地区：[1]江苏省阜宁县中医院内科,江苏阜宁224400

出　　处：《糖尿病新世界》2020年第22期65-67,共3页Diabetes New World Magazine

摘　　要：目的探究阿卡波糖、二甲双胍联合胰岛素类似物治疗2型糖尿病体型偏胖(BMI>24 kg/m^2)患者的短期疗效。方法选择2016年3月—2020年5月在该院接受治疗的108例2型糖尿病体型偏胖者患者作为对象。基于随机数表法,均分为对照组和观察组,每组54例。对照组给予二甲双胍联合胰岛素类似物治疗,观察组则予以阿卡波糖、二甲双胍联合胰岛素类似物治疗。分析比对两组对象临床疗效、胰岛素用量及夜间低血糖发生率。结果观察组治疗总有效率(96.30%)明显高于对照组(81.48%),数据差异有统计学意义(χ^2=6.000,P=0.014);观察组高于0.6 U/(kg·d)总胰岛素用量的患者占比率(51.85%)明显低于对照组(75.92%),数据差异有统计学意义(χ^2=6.783,P=0.009);且观察组夜间低血糖发生率(1.85%)显著低于对照组(18.52%),数据差异有统计学意义(χ^2=8.199,P=0.004)。结论采用阿卡波糖、二甲双胍联合胰岛素类似物治疗2型糖尿病体型偏胖患者疗效显著,能提高治疗有效率,减少胰岛素用量,缩短高血糖水平时间,降低夜间低血糖发生率。Objective To explore the short-term efficacy of acarbose,metformin combined with insulin analogues in the treatment of obese patients with type 2 diabetes(BMI>24 kg/m2).Methods The period from March 2016 to May 2020 was selected as the study time zone,and 108 patients with obese type 2 diabetes who were treated in the hospital in this time zone were selected as the subjects.Based on the random number table method,they were divided into control group and observation group,54 cases in each group.The control group was treated with metformin combined with insulin analogs,and the observation group was treated with acarbose,metformin combined with insulin analogs.Analyze and compare the clinical efficacy,insulin dosage and the incidence of night hypoglycemia in the two groups.Results The total effective rate of treatment in the observation group(96.30%)was significantly higher than that of the control group(81.48%),and the difference was statistically significant(x^2=6.000,P=0.014);the observation group was higher than 0.6 U/(kg·d)total insulin dosage proportion of patients(51.85%)was significantly lower than that of the control group(75.92%),and the difference was statistically significant(x^2=6.783,P=0.009);and the incidence of night-time hypoglycemia in the observation group(1.85%)was significantly lower than that of the control group(18.52%),the difference was statistically significant(x^2=8.199,P=0.004).Conclusion The use of acarbose,metformin and insulin analogues in the treatment of obese patients with type 2 diabetes has a significant effect.It can improve the treatment efficiency,reduce the amount of insulin,shorten the time of high blood sugar levels,and reduce the incidence of night hypoglycemia.

关 键 词：2型糖尿病 阿卡波糖 二甲双胍 胰岛素 夜间低血糖 短期疗效 

分 类 号：R246.1[医药卫生—针灸推拿学]