细胞因子在静脉血栓栓塞形成中的研究进展  

Research progress of cytokines in venous thromboembolism

作　　者：赵琳 黄安斌[1] ZHAO Lin;HUANG Anbin(Rheumatology Department,Union Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430022,China)

机构地区：[1]华中科技大学同济医学院附属协和医院风湿科,湖北武汉430022

出　　处：《临床医学研究与实践》2021年第1期196-198,共3页Clinical Research and Practice

摘　　要：静脉血栓栓塞症(VTE)包括深静脉血栓(DVT)形成和肺栓塞(PE),具有较高的致残率和致死率。在过去的10年里,随着动物模型的改进,静脉血栓的研究领域取得了较大的突破,揭示了VTE为免疫和炎症相关过程,而不仅仅只是凝血因子依赖性的血栓形成过程。免疫细胞、细胞因子等在VTE的形成和消退过程中起着至关重要的作用。但目前的抗凝治疗仍不具备选择性抑制炎症细胞和途径的能力。在这篇综述中,笔者总结了有关参与静脉血栓形成和(或)消退的细胞因子的知识,旨在为VTE预防和治疗提供相关可能性的靶点。Venous thromboembolism(VTE),which includes deep venous thrombosis(DVT)and pulmonary embolism(PE),has a high disability rate and fatality rate.With the improvement of animal models in the past ten years,the research field of venous thrombosis has made a great breakthrough,which reveals that VTE is a process related to immunity and inflammation rather than just a clotting factor-dependent thrombosis process.Immune cells as well as cytokines play an important role in the formation and regression of VTE.However,the current anticoagulation therapy still lacks the ability to selectively inhibit inflammatory cells and pathways.In this review,the authors summarize the knowledge of cytokines involved in the formation and/or regression of venous thrombosis in order to provide potential targets for the prevention and treatment of VTE.

关 键 词：静脉血栓栓塞症 细胞因子 炎症 

分 类 号：R3[医药卫生—基础医学]