Insight into solute-solute and solute-solvent interactions of semicarbazide hydrochloride in water and D-glucose/D-sucrose+water solutions at temperatures(293.15 to 318.15)K  

作　　者：Ankita Dinesh Chand Anil Kumar Nain 

机构地区：[1]Department of Chemistry,Dyal Singh College,University of Delhi,New Delhi 110003,India [2]Department of Chemistry,University of Delhi,Delhi 110007,India [3]Department of Chemistry,Amity University Dubai Campus,Dubai International Academic City,Dubai,UAE

出　　处：《Chinese Journal of Chemical Engineering》2020年第12期3086-3095,共10页中国化学工程学报（英文版）

摘　　要：The solute-solute and solute-solvent interactions of drug semicarbazide hydrochloride with carbohydrates(Dglucose/D-sucrose)are investigated by using volumetric,viscometric and acoustic properties.The measurements of the densitiesρ,ultrasonic speeds u,and viscositiesη.of semicarbazide hydrochloride in 5% and 10%D-glucose/D-sucrose+water(w/w)solutions were carried out at temperatures(293.15-318.15)K and at pressure,p=101 kPa.The apparent molar volumes,Vϕ,limiting apparent molar volumes,V°ϕ,apparent molar compressibilities,Ks,ϕ,limiting apparent molar compressibilities,K°s;ϕ,partial molar expansibilities,E°ϕ,transfer volumes,V°ϕ;tr and transfer compressibilities,K°s;ϕ;tr have been calculated from the experimental data.The viscosity data were examined by using the Jones-Dole equation and the viscosity A and B coefficients were evaluated.The results are discussed in terms of solute-solute and solute-solvent interactions in these solutions.The structure making/breaking ability of semicarbazide hydrochloride is examined using the sign of temperature derivative of Bcoefficient,dB/dT.

关 键 词：Density Ultrasonic speed Viscosity Semicarbazide hydrochloride Carbohydrates Solute-solvent interactions 

分 类 号：TQ460.1[化学工程—制药化工]