软骨下骨的病理改变及其在骨关节炎发病机制中的作用  

Pathological changes of subchondral bone and their roles in pathogenesis of osteoarthritis

作　　者：陈文杰 李益军 郑小飞 王华军[1] CHEN Wenjie;LI Yijun;ZHENG Xiaofei;WANG Huajun(Joint and Sports Medicine Center,the First Clinical Medical College of Jinan University,the First Affiliated Hospital of Jinan University,Guangzhou,Guangdong 510630,China;不详)

机构地区：[1]暨南大学第一临床医学院/暨南大学附属第一医院骨关节与运动医学中心,广州510630 [2]东莞市石碣医院康复医学科,广东523290

出　　处：《中国骨科临床与基础研究杂志》2020年第4期234-241,共8页Chinese Orthopaedic Journal of Clinical and Basic Research

基　　金：广东省医学科学技术研究基金项目(A2019100);广州市科技计划(3345464565);东莞市社会科技发展(重点)项目(202050715011167)。

摘　　要：骨关节炎是一种常见的慢性退行性病变。现有研究表明,软骨下骨病变在骨关节炎的发生发展过程中起着重要作用。本文阐述骨关节炎软骨下骨的病理改变及其在骨关节炎发病机制中的作用,同时对以软骨下骨为治疗靶点的相关研究进展进行综述,从而为研究骨关节炎发病机制、开发治疗药物提供参考依据。Osteoarthritis is a most common chronic degenerative disease.Current studies have shown that subchondral bone lesions play important roles in the occurrence and development of osteoarthritis.In this paper,the pathological changes of subchondral bone and theirs roles in pathogenesis of osteoarthritis were discussed,the related research progress of subchondral bone as a therapeutic target were reviewed,so as to provide references for exploring the pathogenesis of osteoarthritis and developing treatment drugs.

关 键 词：骨关节炎 软骨 关节 软骨下骨 微结构 骨髓水肿样病变 骨囊肿 钙质沉着症 二磷酸盐类 甲状旁腺素 降钙素 

分 类 号：R684.3[医药卫生—骨科学] R364.3[医药卫生—外科学]