肠道双歧杆菌与心房颤动的相关性研究  

Study on the correlation between the intestinal bifidobacteria and atrial fibrillation

作　　者：金珊珊 黄婉露 张苗苗[1] Jin Shanshan;Huang Wanlu;Zhang Miaomiao(Department of Cardiology,The First Affiliated Hospital of Harbin Medical University(Qun Li District),Harbin 150070,China)

机构地区：[1]哈尔滨医科大学附属第一医院群力院区心内科,150070

出　　处：《中国心血管杂志》2020年第6期543-546,共4页Chinese Journal of Cardiovascular Medicine

摘　　要：目的分析肠道双歧杆菌丰度与心房颤动的相关性。方法纳入2019年6~9月在哈尔滨医科大学附属第一医院就诊的窦性心律和心房颤动患者各70例。收集粪便样本并记录基本临床信息,qRT-PCR定量检测双歧杆菌水平,采用单因素和多因素logistic回归分析双歧杆菌与心房颤动的相关性。结果与窦性心律者相比,心房颤动患者左房内径明显增加(45.3 mm比37.7 mm,P<0.001),粪便Bifidobacterium animalis ssp.lactis(P<0.001)和Bifidobacterium breve(P<0.001)丰度显著降低。与阵发性心房颤动患者相比,持续性房颤患者Bifidobacterium animalis ssp.lactis(t=3.27,P<0.01)和Bifidobacterium breve(t=6.54,P<0.001)丰度进一步降低。Logistic回归分析结果显示,左房内径(OR=1.54,95%CI:1.22~1.89,P<0.001)、Bifidobacterium animalis ssp.lactis(OR=0.47,95%CI:0.18~0.97,P<0.01)和Bifidobacterium breve(OR=0.23,95%CI:0.12~0.98,P<0.001)与心房颤动独立相关。结论肠道Bifidobacterium animalis ssp.lactis和Bifidobacterium breve可能影响心房颤动的发生发展。Objective To analyze the correlation between the abundance of intestinal bifidobacteria and atrial fibrillation(AF).Methods A total of 70 sinus rhythm patients and 70 AF patients were enrolled in First Affiliated Hospital of Harbin Medical University from June 2019 to September 2019.The fecal samples of patients were collected and the basic clinical information was recorded.The level of bifidobacteria was quantitatively detected by reverse transcription quantitative real-time PCR(qRT-PCR).The univariate and multivariate logistic regression analysis were performed to analyze the relationship between Bifidobacteria and AF.Results Compared with people with sinus rhythm,patients with AF had a significant increase in the inner diameter of the left atrium(45.3 mm vs.37.7 mm,P<0.001),and a significant decrease in the abundance of the intestinal Bifidobacterium animalis ssp.lactis(P<0.01)and Bifidobacterium breve(P<0.001).Compared with paroxysmal AF patients,the abundance of Bifidobacterium animalis ssp.lactis(t=3.27,P<0.001)and Bifidobacterium breve(t=6.54,P<0.001)was further reduced in persistent AF patients group.Logistic regression analysis showed that left atrial diameter(OR=1.54,95%CI:1.22-1.89),Bifidobacterium anis ssp.lactis(OR=0.47,95%CI:0.18-0.97)and Bifidobacterium breve(OR=0.23,95%CI:0.12-0.98)were independent risk factors of AF.Conclusions Intestinal Bifidobacterium animalis ssp.lactis and Bifidobacterium breve may affect the occurrence and development of AF.

关 键 词：心房颤动 肠道菌群 双歧杆菌 

分 类 号：R541.75[医药卫生—心血管疾病]