Micro-patterned hydroxyapatite/silk fibroin coatings on Mg-Zn-Y-Nd-Zr alloys for better corrosion resistance and cell behavior guidance  

作　　者：Lei CHANG Xiangrui LI Xuhui TANG He ZHANG Ding HE Yujun WANG Jiayin ZHAO Jingan LI Jun WANG Shijie ZHU Liguo WANG Shaokang GUAN 

机构地区：[1]School of Materials Science and Engineering,Zhengzhou University,Zhengzhou 450001,China [2]Henan Key Laboratory of Advanced Magnesium Alloy,Zhengzhou 450001,China [3]Key Laboratory of Materials Processing and Mold Technology(Ministry of Education),Zhengzhou University,Zhengzhou 450001,China

出　　处：《Frontiers of Materials Science》2020年第4期413-425,共13页材料学前沿（英文版）

基　　金：supported by the National Natural Science Foundation of China(Grant Nos.51601169,51671175 and 51701184);the National Key Research and Development Program of China(2018YFC1106703);the Key Projects of the Joint Fund of the National Natural Science Foundation of China(U1804251)。

摘　　要：In this study,a micro-patterned hydroxyapatite/silk fibroin(HA-SF)coating was firstly fabricated on the surface of Mg-Zn-Y-Nd-Zr alloy by template-assisted electrospraying technique coupling with spin coating technique.Two types of micro-patterns were achieved with high contour accuracy,namely HA SF(line-pattern)and HA-SF(dot-pattern).The microstructure,composition,surface wettability and corrosion behaviors of the coatings were investigated by SEM,EDS,FTIR,XRD,water contact angle and potentiodynamic polarization test.The results revealed the hydrophilic nature of coatings and two orders of magnitude reduction of corrosion density(icorr)as compared with that of the substrate.All the micro-patterned surfaces promoted the attachment of MC3T3-E1 cells with visible filopodia after 1 d incubation.In addition,coatings with line pattern exhibited the superior guidance to cell migration as compared to dot pattern,and the preference of cell attachment in the convex zone was observed.In summary,the obtained micro-patterned HA-SF coatings possessed the remarkably improvement of anticorrosion ability and good efficacy in guidance of cell attachment and alignment,which can serve as a promising strategy for cellular response modulation at the interface of magnesium-based implants and bone.

关 键 词：magnesium alloy silk fibroin HYDROXYAPATITE micro-patterned surface electrospraying technique 

分 类 号：TG14[一般工业技术—材料科学与工程] R318[金属学及工艺—金属材料]