针灸足三里的分子生物学效应机制研究  

Study on the molecular biological effect mechanism of acupuncture at Zusanli Point

作　　者：梁丽珠[1] 杨良俊 樊湘珍 Liang Lizhu;Yang Liangjun;Fan Xiangzhen(Department of TCM,People’s Hospital of Deyang City,Deyang 618000,China;Department of Gastroenterology,Zhejiang Tongde Hospital,Hangzhou 310012,China;Doctoral Degree Student of Grade 2018,Guangzhou University of Chinese Medicine,Guangzhou 510405,China)

机构地区：[1]四川省德阳市人民医院中医科,618000 [2]浙江省立同德医院消化科,杭州310012 [3]广州中医药大学,510405

出　　处：《国际中医中药杂志》2020年第11期1125-1129,共5页International Journal of Traditional Chinese Medicine

摘　　要：目的探讨针灸足三里的分子生物学机制。方法检索1999年1月1日-2019年4月30日中国期刊全文数据库(CNKI)、中文科技期刊数据库(重庆维普)、中国学术期刊数据库(万方数据)及PubMed数据库中有关针灸足三里治疗疾病的文献,获取足三里治疗疾病的靶点,构建足三里-靶点网络图,同时对靶点进行疾病富集、GO生物过程富集及KEGG通路富集。结果共纳入文献297篇,涉及196个靶点;富集得到6类疾病,包括肿瘤、神经系统、心血管系统、消化系统等疾病,得到18条GO生物过程相关条目与10条信号通路,涉及免疫、细胞因子、促胃液素分泌等信号通路。结论针灸足三里可治疗多个系统的疾病,这与其多靶点、多途径的作用机制密切相关,研究可为今后进一步阐明针灸治疗疾病的作用机制提供依据。Objective To explore the molecular biological effects of Zu-san-li in the treatment of diseases.Methods Literatures in CNKI,Wan-fang and VIP databases on acupuncture and moxibustion treatment of diseases from January 1,1999 to April 30,2019 were retrieved,and the target of Zu-san-li for treating diseases were obtained.The disease enrichment,GO bioprocess enrichment and KEGG pathway enrichment were performed on these targets.Results A total of 297 articles were included,involving 196 targets.Six diseases,mainly including tumors,nervous system,cardiovascular system,digestive system and other diseases,18 GO bioprocess related items and 10 signaling pathways,involving signaling pathways such as immunity,cytokines,and gastrin secretion,what those were enriched.Conclusions Acupuncture at Zu-san-li can treat diseases of multiple systems,which is related to its multi-target and multi-path mechanism.The study can provide a basis for further elucidating the mechanism of action of acupuncture treatment.

关 键 词：穴 足三里 针灸疗法 靶点网络 作用机制 

分 类 号：R246[医药卫生—针灸推拿学]