儿童急性呼吸道病毒感染986例抗原检测及分析  

Antigen Detection and Analysis of 986 Children with Acute Respiratory Virus Infection

作　　者：朱琳 Zhu Lin(Department of Laboratory Medicine,Kaifeng Children's Hospital,Kaifeng 475000)

机构地区：[1]开封市儿童医院检验科,开封475000

出　　处：《数理医药学杂志》2021年第1期62-64,共3页Journal of Mathematical Medicine

摘　　要：目的:分析儿童急性呼吸道病毒感染的病毒病原分布情况,了解儿童病毒感染的病原学趋势,为临床治疗提供参考。方法:收集某院确诊为急性呼吸道感染的986例患儿鼻咽分泌物,通过直接免疫荧光法进行7项呼吸道病毒抗原检测,分析检测结果。结果:986例确诊为急性呼吸道感染的儿童中,7种常见呼吸道病毒共检出348例,检出率35.29%。0~6月儿童病毒总阳性率最高,随着年龄的增长,病毒阳性率逐渐下降。0~6月阳性率明显高于6月~1岁、1~3岁及3岁以上,6月~1岁阳性率明显高于1~3岁及3岁以上,差异均具有统计学意义(P<0.05);但1~3岁与3岁以上阳性率对比无明显差异,不具有统计学意义(P>0.05)。第一季度病毒检出率占比41.95%,第二季度病毒检出率占比11.49%,第三季度病毒检出率占比12.64%,第四季度病毒检出率占比33.91%。第一季度、第四季度检出率占比明显高于第二季度、第三季度,差异具有统计学意义(P<0.05)。结论:病毒感染是儿童急性呼吸道感染的主要病原,临床通过直接免疫荧光法进行检测,能为诊断提供全面的参考,保证药物治疗的针对性与合理性,避免抗生素滥用的情况,具有较高的价值。Objective:To analyze the distribution of viral pathogens in children with acute respiratory viral infections,to understand the pathogenic trends of viral infections in children,and to provide references for clinical treatment.Methods:The nasopharyngeal secretions of 986 children diagnosed with acute respiratory infections in a hospital were collected,and seven respiratory virus antigens were detected by direct immunofluorescence method,and the test results were analyzed.Results:Among the 986 children diagnosed with acute respiratory infections,a total of 348 cases of 7 common respiratory viruses were detected,with a detection rate of 35.29%.The total positive rate of virus in children from 0~6 months was the highest.With the increase of age,the positive rate of virus gradually decreased.The positive rate of 0~6 months was significantly higher than that of 6 months-1,1~3 and over 3 years old,and the positive rate of 6 months-1 was significantly higher than that of 1~3 years and over 3 years old,and the differences were statistically significant(P<0.05);There was no significant difference in the positive rate between 1~3 years old and over 3 years old,which was not statistically significant(P>0.05).The virus detection rate in the first quarter accounted for 41.95%,the second quarter virus detection rate accounted for 11.49%,the third quarter virus detection rate accounted for 12.64%,and the fourth quarter virus detection rate accounted for 33.91%.The detection rate in the first and fourth quarters was significantly higher than that in the second and third quarters,and the difference was statistically significant(P<0.05).Conclusion:Viral infection is the main pathogen of children's acute respiratory infections.Clinical detection by direct immunofluorescence method can provide a comprehensive reference for diagnosis,ensure the pertinence and rationality of drug treatment,and avoid the abuse of antibiotics,which has high value.

关 键 词：急性呼吸道病毒感染 抗原检测 分析 

分 类 号：R725.6[医药卫生—儿科]