急性有机磷农药中毒救治及解毒机制研究  

Study on treatment and detoxification mechanism of acute organophosphorus pesticide poisoning

作　　者：唐启令[1] 丁月霞[1] 郑文文[1] 王菲[1] Tang Qiling;Ding Yuexia;Zheng Wenwen;Wang Fei(Department of Pharmacy,the Affiliated Yantai Yuhuangding Hospital of Qingdao University,Yantai,Shandong 264000,China)

机构地区：[1]青岛大学附属烟台毓璜顶医院药学部,264000

出　　处：《中国基层医药》2020年第24期3068-3072,共5页Chinese Journal of Primary Medicine and Pharmacy

摘　　要：急性有机磷农药中毒(AOPP)是常见的急危重症之一,为提高临床救治率,多种新型治疗方法在临床得到认可。本研究就AOPP的中毒机制,经典药物胆碱酯酶复活药、抗胆碱能药的应用近况,其他类药物的新型应用如脂肪乳及血液净化治疗、中西医联合疗法作一综述,全面阐述这些药物及治疗方法在临床中的应用及取得的疗效。Acute organophosphorus pesticide poisoning(AOPP)is one of the common critical diseases.In order to improve the rate of clinical cure,in recent years,many new treatment methods in clinical are recognized.In this paper,we will make a overview from the mechanism of AOPP,the application of classical drug cholinesterase reactivators,anticholinergicdrugs,other new applications such as fat emulsion for AOPP and blood purification therapy,combination therapy of Chinese and Western medicine,comprehensively elaborate the application of these drugs and treatment methods in clinical and therapeutic effect.

关 键 词：中毒 有机磷化合物 胆碱酯酶再激活剂 脂肪乳剂 静脉注射用 血液灌注 血浆置换 

分 类 号：R595.4[医药卫生—内科学]