肺癌和贫血的相关性分析  

Correlation analysis of lung cancer and anemia

作　　者：许书琳 吴京[1] 娄加陶[1] XU Shu-lin;WU Jing;LOU Jia-tao(Department of Clinical Laboratory,Shanghai Chest Hospital,Shanghai Jiao Tong University,Shanghai 200030,China)

机构地区：[1]上海市胸科医院,上海交通大学附属胸科医院检验科,上海200030

出　　处：《上海交通大学学报（医学版）》2020年第11期1500-1504,共5页Journal of Shanghai Jiao tong University:Medical Science

摘　　要：目的·分析肺癌患者的基本资料、临床病理特征、抗肿瘤治疗方案及预后与其贫血的相关性。方法·收集2013年8月—2014年11月收治的246例肺癌患者的临床资料和实验室指标。根据抗肿瘤治疗后患者的贫血情况,将其分成贫血组和非贫血组;根据其生存年限,将其分成存活组和死亡组。采用χ2检验、t检验和秩和检验比较不同组患者的贫血及预后的相关因素,并采用Spearman相关系数分析贫血组患者血红蛋白水平和贫血相关因素的关系。结果·抗肿瘤治疗后,有175例(71.1%)患者发生贫血,且以轻度贫血为主。以铂类药物放射/化学治疗方案进行抗肿瘤治疗,易造成患者贫血(P=0.000)。贫血组与非贫血组患者在肿瘤分期、体力状态评分、继发疾病和血清白蛋白水平间差异具有统计学意义(均P<0.05),且贫血组患者的血清白蛋白水平与血红蛋白水平呈正相关(r=0.498,P=0.000)。与死亡组比较,存活组患者的血红蛋白、血清白蛋白、血清铁和叶酸水平较高,血清铁蛋白、糖化血红蛋白和乳酸脱氢酶水平较低(均P<0.05)。结论·肺癌患者贫血的发生受多种因素的影响,且与预后相关。因此,贫血治疗应给予足够重视,注重个体化治疗。Objective·To analyze the correlation between basic information,clinicopathological characteristics,anti-tumor treatment options,prognosis and anemia in lung cancer patients.Methods·The clinical data and laboratory indexes of 246 patients with lung cancer from August 2013 to November 2014 were collected.According to the occurrence of anemia after the anti-tumor therapy,the patients were divided into anemia group and non-anemia group.And according to the survival time,they were divided into survival group and death group.Chi-square test,t test and rank sum test were used to compare the related factors of anemia and prognosis in different patient groups,and Spearman correlation coefficient was used to analyze the relationship between hemoglobin level and anemia-related factors in anemia group.Results·After anti-tumor therapy,175 patients(71.1%)developed anemia,mainly mild anemia.Anti-tumor treatment with platinum-based chemoradiotherapy could easily cause anemia(P=0.000).There were significant differences between the anemia group and the non-anemia group in tumor stage,Performance Status score,secondary disease and serum albumin level(all P<0.05).And the hemoglobin level in anemia group was positively correlated with the serum albumin level(r=0.498,P=0.000).Compared with the death group,the levels of hemoglobin,serum albumin,serum iron and folic acid in the survival group were higher,and the levels of serum ferritin,glycosylated hemoglobin and lactate dehydrogenase in the survival group were lower(all P<0.05).Conclusion·The occurrence of anemia in lung cancer patients is affected by many factors,and is related to the prognosis.Therefore,the treatment of anemia should be given enough attention,and attention should be paid to individualized treatment.

关 键 词：肺癌 癌性贫血 血红蛋白 血清白蛋白 血清铁蛋白 

分 类 号：R446.112[医药卫生—诊断学]