vdr及slc11a1基因多态性与结核病治疗结局的遗传关联研究  

Genetic association of VDR and SLC11A1 gene polymorphisms with tuberculosis treatment outcome

作　　者：张燕[1] 陈阳贵[2] 刘亚洁 古丽娜扎尔·艾克拜尔 李德洋 加依娜·拉兹别克 曹明芹[1] ZHANG Yan;CHEN Yang-gui;LIU Ya-jie;GULINAZHAER Aikebaier;LI De-yang;JIAYINA Razbek;CAO Ming-qin(School of Public Health,Xinjiang Medical University,Urumqi,Xinjiang 830011,China)

机构地区：[1]新疆医科大学公共卫生学院,新疆乌鲁木齐830011 [2]乌鲁木齐市疾病预防控制中心

出　　处：《现代预防医学》2020年第24期4523-4526,4531,共5页Modern Preventive Medicine

基　　金：国家自然科学基金-新疆联合基金项目(U1903123)。

摘　　要：目的分析vdr、slc11a1基因多态性与结核病治疗结局的相关性,为结核病的精准防治提供科学的参考信息。方法选取2018年1-12月在乌鲁木齐市结核病管理信息专报系统登记的结核病患者作为研究对象,回顾性收集结核病患者的人口学特征、临床信息及血液制品,采用logistic回归和决策树模型分析结核病治疗结局的影响因素。结果调整治疗管理方式、痰涂片检查结果、年龄等因素后,rs17235409与结核病治疗结局存在相关性(P<0.05),基因型为G/A(OR=2.371,95%CI:1.106~5.081)的结核病患者发生治疗失败的风险较高。此外,决策树模型提示rs2228570基因型为G/A的结核病患者发生治疗失败的风险较高。结论slc11a1及vdr基因多态性与结核病治疗结局存在一定关联性,可针对不同的结核病患者采取个体化的治疗方案,对结核病的精准防控具有重要的实践意义。Objective To analyze the correlation between VDR,SLC11 A1 gene polymorphisms and tuberculosis treatment outcome,in order to provide scientific reference information for the precise prevention and treatment of tuberculosis.Methods The tuberculosis patients registered in the tuberculosis management information report system in Urumqi from January to December 2018 were selected as the research subjects,and collect their demographic characteristics,clinical information and blood products retrospectively.Logistic regression and decision tree models were used to analyze the influencing factors of tuberculosis treatment outcome.Results After adjusting the treatment management,sputum smear test results,age and other factors,rs17235409 was correlated with the outcome of tuberculosis treatment(P<0.05),and tuberculosis patients with G/A genotype(OR=2.371,95%CI:1.106-5.081)are at higher risk of treatment failure.In addition,the decision tree model showed that tuberculosis patients with rs2228570 genotype G/A had a higher risk of treatment ffailure.Conclusion SLC11 A1 and VDR gene polymorphisms are related to the treatment outcome of tuberculosis.Individualized treatment plans can be adopted for different tuberculosis patients,which have important practical significance for the accurate prevention and control of tuberculosis.

关 键 词：结核病 治疗结果 维生素D受体 slc11a1 多态性 

分 类 号：R34[医药卫生—基础医学] R183