sST2在不同类型心脏疾病中的变化及诊治价值  

Changes of sST2 level in different types of heart diseases and its clinical value in diagnosis and treatment of heart diseases

作　　者：贾文宁 孙国举[1] JIA Wenning;SUN Guoju(Department of Cardiology,the First Affiliated Hospital of Zhengzhou University,Zhengzhou 450000,China)

机构地区：[1]郑州大学第一附属医院心内科,郑州450000

出　　处：《临床心血管病杂志》2020年第11期1053-1057,共5页Journal of Clinical Cardiology

摘　　要：目的:观察不同类型心脏疾病中血清可溶性ST2(sST2)水平的变化及在不同心功能分级中的差异。方法:选取2019年2月—2020年5月郑州大学第一附属医院心内科收治的扩张型心肌病30例,冠心病30例,非瓣膜性心房颤动(房颤)30例,选取同期健康体检者20例作为对照组。比较不同类型心脏疾病sST2水平差异及不同心功能分级(NYHA分级)sST2水平差异。结果:与对照组(17.90±7.21)ng/ml比较,扩张型心肌病及冠心病组sST2升高显著,分别为(33.38±15.46)ng/ml、(27.73±12.65)ng/ml,差异有统计学意义(P<0.05)。随心功能分级的增加,sST2水平逐渐升高,组间比较差异有统计学意义(P<0.05)。sST2与氨基末端脑钠肽前体(NT-proBNP)联合诊断对心力衰竭严重程度诊断的准确性为92.5%。结论:sST2在不同类型心脏疾病中的水平不同,且与心功能分级呈正相关。Objective: To observe the changes of serum soluble ST2(sST2) levels in different types of heart diseases and their distribution in different cardiac function grades Method: The 90 patients with different types of heart diseases treated in the Department of Cardiology of the first affiliated Hospital of Zhengzhou University from February 2019 to May 2020 were selected, including 30 cases of dilated cardiomyopathy, 30 cases of coronary heart disease and 30 cases of non-valvular atrial fibrillation. The 20 healthy subjects in the same period were selected as the control group. The differences of sST2 levels in different types of heart diseases and sST2 levels in different cardiac function grades(NYHA classification) were compared. Result: Compared with the control group(17.90 ±7.21) ng/ml, the sST2 of dilated cardiomyopathy and coronary heart disease increased significantly, were(33.38 ±15.46) ng/ml and(27.73 ±12.65) ng/ml, respectively. With the increase of cardiac function grade, the level of sST2 increased gradually, and there was significant difference between the two groups(P<0.05). The accuracy of combined diagnosis of sST2 and NT-ProBNP in the diagnosis of the severity of heart failure was 92.5%. Conclusion: The level of sST2 is different in different types of heart disease, and it is positively correlated with the grade of cardiac function.

关 键 词：心脏疾病 血清可溶性ST2 心功能分级 临床应用 

分 类 号：R541[医药卫生—心血管疾病]