凋亡抑制蛋白Survivin和p300/CBP相关因子在宫颈癌组织中的表达以及临床意义  

Expression and clinical significance of Survivin and p300/CBP related factor in cervical cancer

作　　者：李蕾 王青青 许艳华 张俊涛 LI Lei;WANG Qing-qing;XU Yan-hua;ZHANG Jun-tao(Department of Pathology,Dongying District People′s Hospital of Dongying City,Shandong Province,Dongying257000,China;Department of Pathology,Bin Zhou People′s Hospital,Shandong Province,Binzhou256600,China)

机构地区：[1]山东省东营市东营区人民医院病理科,山东东营257000 [2]山东省滨州市人民医院病理科,山东滨州256600

出　　处：《中国当代医药》2020年第36期174-177,共4页China Modern Medicine

摘　　要：目的探讨凋亡抑制蛋白Survivin和p300/CBP相关因子在宫颈癌组织中的表达情况,以及两者之间的关联性。方法选取2016年2月~2020年2月东营市东营区人民医院收治的40例宫颈癌患者和10例非宫颈癌患者作为研究对象,分为宫颈癌组和非宫颈癌组。应用免疫组织化学SP法检测Survivin蛋白和p300/CBP相关因子在宫颈组织中的表达,比较分析两组Survivin蛋白和p300/CBP相关因子表达的特点以及临床意义。结果宫颈癌组Survivin蛋白阳性表达率(72.5%)高于非宫颈癌组(0.0%),差异有高度统计学意义(χ^2=17.262,P<0.001);Survivin蛋白的阳性表达率随宫颈癌肿瘤分期及病理分级的增高而逐渐增高(P<0.05),与患者年龄和组织学类型无关(P>0.05);宫颈癌组p300/CBP相关因子阳性表达率(40.0%)低于非宫颈癌组(80.0%),差异有统计学意义(χ^2=5.128,P=0.024);p300/CBP相关因子在子宫颈癌组织中的阳性表达率随宫颈癌肿瘤分期及病理分级的增高而逐渐降低(P<0.05),与患者年龄和组织学类型无关(P>0.05)。Survivin蛋白和p300/CBP相关因子在宫颈癌组织中的表达有较密切的关联性。结论Survivin蛋白的异常高表达和p300/CBP相关因子的低表达甚至不表达在宫颈癌的发展中起一定作用,与宫颈癌的临床分期和病理分级有关,并且提示宫颈癌预后不良。两种蛋白之间亦存在着关联性。Objective To explore the expression of Survivin and p300/CBP-related factor in cervical carcinoma and the relationship between the two factors.Methods A total of 40 patients with cervical carcinoma and 10 patients without cervical carcinoma who were admitted to Dongying District People′s Hospital of Dongying city from February 2016 to February 2020 were selected and were divided into cervical carcinoma group and normal cervical tissue group.The Immunohistochemical SP method was used to detect the expression of Survivin protein and p300/CBP-related factor in cervical tissue,and the expression characteristics and clinical significance of Survivin protein and p300/CBP-related factor were compared and analyzed.Results The positive expression rate of Survivin protein in cervical carcinoma group(72.5%)was higher than that in normal cervical tissue group(0.0%),the difference was highly statistically significant(χ^2=17.262,P<0.001).The positive expression rate of Survivin protein gradually increased with the increase of neoplasm stage and pathologic grade(P<0.05)and had no relationship with the age and histological type of the patient(P>0.05).The positive expression rate of p300/CBP-related factor in cervical carcinoma group(40.0%)was lower than that of normal cervical tissue group(80.0%),the difference was statistically significant(χ^2=5.128,P=0.024).The positive expression rate of p300/CBP-related factor gradually increased with the increase of neoplasm stage and pathologic grade(P<0.05),and had no relationship with the age and histological type of the patient(P>0.05).The expression of Survivin protein and p300/CBP-related factor in cervical carcinoma was closely related.Conclusion The abnormal high expression of Survivin protein and the low expression of p300/CBP related factor play a role in cervical carcinoma,and are related to the clinical stage and tumor grade of cervical carcinoma,suggesting that the prognosis of cervical carcinoma is poor.There was also a correlation between the two proteins.

关 键 词：SURVIVIN蛋白 p300/CBP相关因子 宫颈癌 凋亡 

分 类 号：R446.1[医药卫生—诊断学]