HIV感染者免疫重建不良发生的机制与相关性因素  

The mechanisms and related factors of poor immune reconstitution in HIV infected individuals

作　　者：赵一霖 蒋悦 凌虹[2] 庄敏[1] Zhao Yilin;Jiang Yue;Ling Hong;Zhuang Min(Department of Microbiology,Harbin Medical University,Wu Lien-Teh Institute,Heilongjiang Provincial,Key Laboratory for Infection and Immunity,Key Laboratory of Pathogen Biology in Heilongjiang Provincial Education Institute,Harbin 150081,China;Department of Immunology,Harbin Medical University,Harbin 150081,China)

机构地区：[1]哈尔滨医科大学微生物学教研室,伍连德研究所黑龙江省感染与免疫重点实验室,黑龙江省普通高校病原生物学重点实验室,150081 [2]哈尔滨医科大学免疫学教研室,150081

出　　处：《国际免疫学杂志》2020年第6期603-609,共7页International Journal of Immunology

基　　金：国家自然科学基金(81871654)。

摘　　要：在抗逆转录病毒治疗后,有9%~45%的人类免疫缺陷病毒(human immunodeficiency virus,HIV)感染者尽管达到了病毒学抑制,但其CD4+T细胞数水平没有恢复,这些感染者被称为免疫重建不良的HIV感染者或免疫无应答者(immunological non-responders,INRs)。免疫重建不良者发生AIDS和non-AIDS的风险更高,预期寿命更低,因此为感染者的治疗带来困难。本文针对免疫重建不良发生的可能相关因素及其与疾病进展的关系进行综述,探讨免疫重建不良发生的机制,为评估疾病预后以及有针对性的优化治疗方案提供参考。After antiretroviral therapy,9%to 45%of HIV infected individuals have achieved virological suppression,but CD4+T cell counts did not recover.These people are called as HIV infected individuals with poor immune reconstitution(PIR)or immune non-responders(INRs).INRs have a higher risk of developing AIDS and non-AIDS,and have a lower life expectancy,that resulted in difficulty for treatment.In this review,we aim to discuss the factors related to INR and its relationship with disease progression.Exploring mechanisms of INR development will provide ideas for evaluating disease prognosis and optimization of the treatment plans.

关 键 词：人类免疫缺陷病毒 抗逆转录病毒治疗 免疫重建不良 免疫无应答者 CD4+T细胞 

分 类 号：R512.91[医药卫生—内科学]