NLRP3炎症小体激活转录后及翻译后调节机制研究进展  

Research progress on post-transcription and post-translational regulatory mechanisms of NLRP3 inflammasomes activation

作　　者：陈江龙 陈砼 吕志宝[1] Chen Jianglong;Chen Tong;Lv Zhibao(Department of General Surgery,Shanghai Children's Hospital,Shanghai Jiao Tong University,Shanghai 200062,China)

机构地区：[1]上海市儿童医院上海交通大学附属儿童医院普外科,200062

出　　处：《国际免疫学杂志》2020年第6期670-676,共7页International Journal of Immunology

基　　金：国家自然科学基金(81871194);上海市科学技术委员会基金(18ZR1431300)。

摘　　要：NLRP3炎症小体是一种多蛋白复合体,是固有免疫系统的重要组成部分,可以识别病原体与细胞损伤,诱导炎症因子白细胞介素(inter leukin,IL)IL-1β与IL-18的分泌,介导细胞焦亡,调节机体炎症信号通路。NLRP3炎症小体在众多病理生理过程中发挥重要作用,适度的炎性反应有利于免疫细胞的趋化以对抗病原入侵、促进损伤修复,然而过度的炎性激活会导致许多疾病。因此NLRP3炎症小体的激活调节对机体维持生理稳态至关重要的。文章主要就NLRP3炎症小体激活转录后与翻译后调节机制研究进展进行综述。NLRP3 inflammasomes is a multi-protein complex and an important part of the innate immune system.It recognizes pathogens and cell damage,induces the secretion of interleukin(IL)-1 beta and IL-18,mediates pyroptosis,and regulates inflammatory signaling pathways in the body.NLRP3 inflammasomes plays an important role in many pathophysiological processes.Moderate release of inflammatory substances facilitates chemotaxis of immune cells to fight pathogen invasion and promote injury repair,while excessive inflammatory activation can lead to many diseases.Therefore,the activation and regulation of NLRP3 inflammasomes are crucial for the maintenance of physiological homeostasis.This review focused on the progress of post-transcriptional and post-translational regulation mechanisms of NLRP3 inflammasomes activation.

关 键 词：NLRP3炎症小体 转录后调节 翻译后修饰 

分 类 号：R692[医药卫生—泌尿科学]