半夏泻心汤联合三联疗法治疗幽门螺旋杆菌相关性胃炎的Meta分析  

Meta-analysis of Banxia Xiexin Decoctioncombined with Triple Therapy for Helicobacter pylori-associated gastritis

作　　者：许文娟 彭瑶[1] 刘富林[1] 夏旭婷 XU wenjuan;PENG yao;LIU fulin;XIA xuting(Hunan University of Chinese Medicine,Changsha 410208,China)

机构地区：[1]湖南中医药大学,湖南长沙410208

出　　处：《中国民族民间医药》2020年第24期75-79,共5页Chinese Journal of Ethnomedicine and Ethnopharmacy

基　　金：国家自然科学青年基金(81603597);湖南省中医药科研计划项目(No.201954)。

摘　　要：目的:系统评价半夏泻心汤联合三联疗法治疗幽门螺旋杆菌相关性胃炎(HAG)的有效性及安全性。方法:计算机检索CNKI、VIp、WanFang、CBM、pubMed数据库,纳入相关的随机对照研究(RCT),检索时间期限为建库至2020年1月15日,运用EndNoteX7软件对检索所得的重复文献进行剔除,严格根据纳入和排除标准确定最终纳入文献,对纳入文献进行方法学质量评价,运用Revman5.3软件进行Meta分析。结果:最终纳入16篇文献。Meta分析结果显示:半夏泻心汤联合三联疗法治疗HAG总有效率[RR=1.25,95%CI(1.19,1.31),P<0.05]、Hp转阴率[RR=1.26,95%CI(1.18,1.35),P<0.05]优于对照组,且不良反应率[RR=0.41,95%CI(0.23,0.73),P<0.05]小于对照组,差异均具有统计学意义。结论:相比于单用西药,半夏泻心汤联合三联疗法治疗HAG疗效更好,且更安全。但由于本次研究纳入的文献数量较少且质量不高,所得结果还需更多、更高质量的RCT进行验证。Objective To systematically review of the efficacy and safety of Banxia Xiexin Decoction combined with triple therapy in the treatment of Helicobacter pylori-associated gastritis.Methods CNKI、VIp、WanFang、CBM、pubMed were searched online to collect randomized controlled trials(RCTs)of Banxia Xiexin Decoction combined with triple therapy for Helicobacter pylori-associated gastritis from inception to January 15,2020.Eliminate duplicate documents retrieved with EndNoteX7 software.Finalize the included documents strictly according to the inclusion and exclusion criteria,and evaluate the methodologicalquality of the included documents.Meta Analysis with Revman5.3 Software.Resluts Finally included 16 articles.The meta-analysis results show that the total effective rate of Banxia Xiexin Decoction combined with triple therapy in the treatment of HAG[RR=1.25,95%CI(1.19,1.31),P<0.05],Hp negative rate[RR=1.26,95%CI(1.18,1.35),P<0.05]is better than the control group,and the adverse reaction rate[RR=0.41,95%CI(0.23,0.73),P<0.05]is smaller than the control group,the differences are statistically significant.Conclusion Compared with western medicine alone,Banxia Xiexin Decoction combined with triple therapy is more effective and safer in treating HAG.However,due to the small number and low quality of the literature included in this study,more and higher quality RCTs are needed to verify the results.

关 键 词：半夏泻心汤 三联疗法 幽门螺旋杆菌相关性胃炎 META分析 

分 类 号：R256.3[医药卫生—中医内科学]