不同年龄段老年医院获得性尿路感染患者的病原学特点及耐药分析  

Etiological characteristics and drug resistance of hospital-acquired urinary tract infection in elderly patients with different age

作　　者：王秋野 管仲莹 王沈峰 WANG Qiu-ye;GUAN Zhong-ying;WANG Shen-feng(Department of Clinical Laboratory,the Second Hospital Affiliated to Liaoning University of Traditional Chinese Medicine,Shenyang 110034,China)

机构地区：[1]辽宁中医药大学附属第二医院检验科,辽宁沈阳110034

出　　处：《实用药物与临床》2020年第12期1131-1134,共4页Practical Pharmacy and Clinical Remedies

摘　　要：目的探讨不同年龄段老年医院获得性尿路感染患者的病原学特点及耐药情况。方法选取本院2016年3月至2019年12月收治的745例医院获得性尿路感染患者作为研究对象,对其尿液标本进行细菌培养及药敏试验。结果745例患者检出致病菌745株,60岁以下患者检出116株(15.5%)、61~70岁患者检出130株(17.5%)、71~80岁患者检出212株(28.5%)、80岁以上患者检出287株(38.5%)。随着年龄的增长,屎肠球菌的感染率逐渐升高,而大肠埃希菌感染率呈递减趋势;抗菌药物的耐药率随着年龄的增长有不同程度的增高(P<0.05),80岁以上患者尤为显著,其中大肠埃希菌对阿米卡星、头孢他啶、头孢吡肟,肺炎克雷伯菌对碳青霉烯类抗菌药物,屎肠球菌对氨苄西林、高水平链霉素、环丙沙星、左氧氟沙星、四环素以及粪肠球菌对环丙沙星、左氧氟沙星、四环素的耐药率均升高(P<0.05)。结论老年医院获得性尿路感染患者的发病率随年龄的增长而升高,不同年龄段的病原学特点和耐药情况存在差异。Objective To analyze the etiological characteristics and drug tolerance of hospital-acquired urinary tract infection in elderly patients at different age.Methods A total of 745 of patients with hospital-acquired urinary tract infection from March 2016 to December 2019,the urine samples were cultured and analyzed for drug resistance.Results Totally 745 strains of pathogen were detected from 745 patients,in which 116 strains(15.5%)from patients less than 60 years old,130 strains(17.5%)from patients at 61~70 years old,212 strains(28.5%)from patients at 71~80 years old,and 287 strains(38.5%)from patients more than 80 years old.The detection rates of E.coli decreased along with the increase of ages(P<0.05),while the rate of E.faecium infection increased.The drug resistance rates of E.coli increased along with the increase of age in patients,especially for the patients more than 80 years old,and the resistance rates of E.coli against amikacin,ceftazidime and cefepime,K.pneumoniae against carbapenem antibiotics,E.faecium against ampicillin,high-level streptomycin,ciprofloxacin,levofloxacin and tetracycline,and E.faecalis against ciprofloxacin,levofloxacin and tetracycline were all increased(P<0.05).Conclusion The incidence rate of elderly patients with hospital-acquired urinary tract infection increases with age,and the etiological characteristics and drug resistance vary among patients in different age groups.

关 键 词：老年 尿路感染 病原学 耐药 

分 类 号：R446.5[医药卫生—诊断学] R691.3[医药卫生—临床医学]