海藻共附生真菌活性天然产物研究进展  

Advances in Active Natural Products from Marine Alga derived Fungi

作　　者：杨曦亮[1] 王健娇 姜睿 刘永宏[2] 周雪峰[2] YANG Xiliang;WANG Jianjiao;JIANG Rui;LIU Yonghong;ZHOU Xuefeng(Medical College,Wuhan University of Science of Technology,Wuhan,Hubei,430081,China;Guangdong Key Laboratory of Marine Materia Medica,South China Sea Institute of Oceanology,Chinese Academy of Sciences,Guangzhou,Guangdong,510301,China)

机构地区：[1]武汉科技大学医学院,湖北武汉430081 [2]中国科学院南海海洋研究所,广东省海洋药物重点实验室,广东广州510301

出　　处：《广西科学》2020年第5期462-474,共13页Guangxi Sciences

基　　金：国家自然科学基金项目(31900286,81973235,21977102);广东省自然科学基金杰出青年项目(2019B151502042)资助。

摘　　要：海藻共附生真菌次级代谢产物结构类型多样、骨架新颖、活性丰富,为新型海洋药物先导化合物的发现提供了宝贵的来源。本文以生物活性对海藻共附生真菌来源的天然产物进行分类,从抗菌、抗肿瘤、抗氧化、抗炎、浮游生物抑制等方面,对2006年以来报道的海藻共附生真菌来源的112个活性天然产物进行概述,为海藻及其共附生微生物的进一步研究与开发提供参考。The secondary metabolites from marine alga-derived possess diverse structure types,novel skeletons and abundant activities,and provide a valuable source for the screening and discovery of new marine drug lead compounds.In this paper,we classify natural products from marine alga-derived fungi according to the types of biological activities.From the aspects of antibacterial,anti-tumor,antioxidant,anti-inflammatory,plankton inhibition,etc.,112 activities from marine alga-derived fungi reported in 2006 are summarized,which provides references for further research of marine alga and marine alga-derived microorganisms.

关 键 词：海藻共附生真菌 次级代谢产物 天然产物 生物活性 海洋药物 

分 类 号：R284.1[医药卫生—中药学] R284.2[医药卫生—中医学]