抗阿尔茨海默病真菌来源天然产物研究进展  

Research Progress of the Fungus derived Natural Products with Anti Alzheimer's Potential

作　　者：王俊锋[1,2] 陈伟豪 陈春梅 刘永宏 WANG Junfeng;CHEN Weihao;CHEN Chunmei;LIU Yonghong(CAS Key Laboratory of Tropical Marine Bio resources and Ecology,Guangdong Key Laboratory of Marine Materia Medica,South China Sea Institute of Oceanology,Chinese Academy of Sciences,Guangzhou,Guangdong,510301,China;Southern Marine Science and Engineering Guangdong Laboratory(Guangzhou),Guangzhou,Guangdong,511458,China;University of Chinese Academy of Sciences,Beijing,100049,China;Guangxi University of Chinese Medicine,Nanning,Guangxi,530200,China)

机构地区：[1]中国科学院南海海洋研究所,中国科学院热带海洋生物资源与生态重点实验室,广东省海洋药物重点实验室,广东广州510301 [2]南方海洋科学与工程广东省实验室(广州),广东广州511458 [3]中国科学院大学,北京100049 [4]广西中医药大学,广西南宁530200

出　　处：《广西科学》2020年第5期475-486,共12页Guangxi Sciences

基　　金：南方海洋科学与工程广东省实验室(广州)团队项目(GML2019ZD0406);广西中医药大学海洋药物研究院团队科研专项(2018ZD005);广西八桂学者专项(05019055);广西中医药大学岐黄工程高层次人才团队培育项目(2018006)资助。

摘　　要：阿尔茨海默病(Alzheimer's Disease,AD),即老年痴呆症,是一种多因素诱导的慢性神经系统退行性疾病,多发于65岁以上老年人群。目前临床上没有治疗AD的特效药,现有的药物只能减缓发病进程,无法预防和治愈AD。关于AD的发病机制,目前研究认为有β淀粉样蛋白沉积毒性假说、神经炎症假说、氧化应激假说和乙酰胆碱能缺失假说等。自然界中真菌分布广泛,数量繁多且能产生大量具有生物活性的代谢产物。已有不少研究表明真菌来源的天然产物具有神经保护作用,有成为抗AD药物先导化合物的潜力。本文从AD发病机制假说的角度出发,综述了具有抗AD潜力的真菌来源天然产物及其相关生理活性或作用机制,为探寻新的抗AD真菌来源天然药物提供参考。Alzheimer's Disease(AD) is a chronic neurodegenerative disease induced by multiple factors,which mostly occurs in the elderly over 65 years old.At present,there are no effective drugs for the treatment of AD in clinical practice.The existing drugs can only slow the progression of the disease,but cannot prevent and cure AD.Regarding the pathogenesis of AD,current research believes that there are hypothesis of amyloid β deposition toxicity,neuro-inflammatory,oxidative stress and acetylcholinergic deficiency hypothesis.Fungi in nature are widely distributed and can produce a large number of metabolites with biological activity.Many studies have shown that natural products derived from fungi have neuroprotective effects and have the potential to become leading compounds of anti-AD drugs.From the perspective of AD pathogenesis hypothesis,this article reviews the natural products of fungal origin with anti-AD potential and their related physiological activities or mechanism,and provides a reference for exploring new anti-AD fungal natural medicines.

关 键 词：阿尔茨海默病 真菌天然产物 神经保护 β 淀粉样蛋白 神经炎症 

分 类 号：R931[医药卫生—生药学]