慢性乙型肝炎患者血清纤维蛋白原样蛋白1与HBV DNA载量的相关性分析  

The analisis of the correlation between serum fibrinogen-like protein 1 and HBV DNA load in patients with chronic hepatitis B

作　　者：谢明容[1] 张川 XIE Ming-rong;ZHANG Chuan(Department of gastroenterology,Ya’an People’s Hospital,Ya’an 625000,Sichuan,China;Department of Emergency treatment,Ya’an People’s Hospital,Ya’an 625000,China)

机构地区：[1]雅安市人民医院消化内科,四川625000 [2]雅安市人民医院急诊科,四川625000

出　　处：《肝脏》2020年第11期1161-1164,共4页Chinese Hepatology

基　　金：雅安市应用技术研究与开发资金项目(2017yyjskf09)。

摘　　要：目的观察慢性乙型肝炎患者的血清纤维蛋白原样蛋白1(FLP1)与乙型肝炎病毒DNA(HBV DNA)载量表达情况,分析患者血清FLP1与HBV DNA载量的相关性。方法选取我院2017年8月至2019年10月期间就诊的204例慢性乙型肝炎患者作为研究对象,根据肝纤维化的严重程度对患者进行分组,分别为S0组(42例)、S1组(39例)、S2组(46例)、S3组(38例)、S4组(39例)。比较5组患者的血清FLP1水平、HBV DNA载量拷贝数的对数值及HBV DNA阳性率,根据HBV DNA载量的拷贝数对数值将患者整体分为<3、3~4、5~6、>6等4组,比较4组的血清FLP1水平;经双变量直线相关检验,分析慢性乙型肝炎患者血清FLP1水平与HBV DNA载量的相关性。结果随着慢性乙型肝炎患者的肝纤维化分级加重,患者的血清FLP1水平降低、HBV DNA载量拷贝数的对数值升高,HBV DNA阳性检出率升高,组间比较差异有统计学意义(P<0.05);随着HPV-DNA载量对数值的升高,患者血清FLP1水平呈下降趋势,各组间比较差异有统计学意义(P<0.05);经双变量Pearson直线相关检验结果显示,慢性乙型肝炎患者的血清FLP1水平与HBV DNA载量拷贝数的对数值呈负相关(r=-0.584,P<0.001)。结论随着慢性乙型肝炎患者FLP1水平降低,患者HBV DNA载量的对数值增加,阳性检出率升高,患者血清FLP1水平与HBV DNA载量间呈负相关,临床工作中可考虑通过检测血清FLP1水平,来监测慢性乙型肝炎患者体内病毒复制情况。Objective To observe the serum level of fibrinogen-like protein 1(FLP1)and hepatitis B virus-deoxyribonucleic acid(HBV DNA)load in patients with chronic hepatitis B(CHB),and analyze the correlation between them.Methods 204 patients with chronic hepatitis B were divided into S0 group(N=42 cases),S1 group(N=39 cases),S2 group(N=46 cases),S3 group(N=38 cases)and S4 group(N=39 cases)according to their gradings of liver fibrosis stages by liver biopsies.The serum FLP1 level,the logarithmic value of the copy numbers of HBV DNA load,and the positive rate of HBV DNA were compared among the five groups.According to the logarithmic value of HBV DNA copy numbers,the patients were divided into<3 group,3~4 group,5~6 group,>6 group.The serum FLP1 levels in these four groups were compared.Moreover,the correlation between serum FLP1 level and HBV DNA load in patients with chronic hepatitis B was analyzed by bivariate linear correlation test.Results With the progression of liver fibrosis in patients with chronic hepatitis B,the serum FLP1 level decreased,whereas the logarithmic value of HBV DNA copy numbers increased,accompanied by an increased positive detection rate of HBV-DNA(P<0.05);With the increase of the logarithmic value of HPV DNA load,the serum FLP1 level showed a downward trend with statistically significant differences(P<0.05);By bivariate pearson linear correlation test it was showed that serum FLP1 levels of patients with chronic hepatitis B were negatively correlated with the logarithmic value of HBV DNA copy numbers(r=-0.584,P<0.001).Conclusion The serum level of FLP1 in chronic hepatitis B patients decrease with the increment of logarithmic value of HBV DNA load and the positive detection rate.There is a negative correlation between serum FLP1 level and HBV DNA load in CHB patients.Serum FLP1 level may therefore be considered as a clinical parameter to monitor the viral replication.

关 键 词：慢性乙型肝炎 HBV DNA载量 血清纤维蛋白原样蛋白1 相关性 

分 类 号：R512.62[医药卫生—内科学]