运动联合补中助长颗粒治疗特发性矮小症临床研究  

Clinical Study on Exercise Combined with Buzhong Zhuzhang Granules for Idiopathic Short Statue

作　　者：孙凤平 崔伟锋[2] 李宁宁 韩雪[1] SUN Fengping;CUI Weifeng;LI Ningning;HAN Xue

机构地区：[1]郑州大学附属儿童医院(河南省儿童医院,郑州儿童医院),河南郑州450053 [2]河南省中医药研究院,河南郑州450004 [3]河南医学高等专科学校,河南郑州451191

出　　处：《新中医》2020年第23期69-72,共4页New Chinese Medicine

基　　金：河南省科技攻关项目(182102310395);河南省医学科技攻关项目(2018020534)。

摘　　要：目的:观察运动联合补中助长颗粒治疗特发性矮小症(ISS)的临床疗效。方法:将76例ISS患儿随机分为观察组和对照组各38例。对照组给予口服补中助长颗粒治疗,观察组在对照组基础上联合中等强度舒展性运动治疗,2组均治疗12个月。比较2组身高、身高增长速度(GV)、身高落后标准差(HtSDS)、体质量指数(BMI)、年龄/骨龄(CA/BA)及血清生长激素峰值(GHP)、血清胰岛素样生长因子-1 (IGF-1)、胰岛素样生长因子结合蛋白3 (IGFBP3)水平,观察治疗期间不良反应发生率。结果:治疗12个月,观察组HtSDS大于对照组,差异有统计学意义(P<0.05)。治疗6个月、12个月,观察组GV大于对照组,血清IGF-1、IGFBP3水平均高于对照组,差异均有统计学意义(P<0.05);2组身高、BMI、CA/BA及血清GHP水平比较,差异均无统计学意义(P>0.05)。2组治疗期间均无不良反应发生。结论:运动联合补中助长颗粒能有效促进ISS患儿生长,其作用机制可能与促进血清IGF-1、IGFBP3水平升高有关,临床使用安全。Objective:To observe the clinical effect of exercise combined with Buzhong Zhuzhang granules for idiopathic short statue(ISS). Methods: A total of 76 cases of ISS children were randomly divided into the observation group and the control group,38 cases in each group. The control group was given oral administration of Buzhong Zhuzhang granules,and the observation group was additionally treated with stretching exercise with moderate intensity based on the treatment of the control group. Both groups were treated for 12 months. The comparison of height, growth rate(GV), height standard deviation score(HtSDS), body mass index(BMI), chronological age/bone age(CA/BA), as well as the levels of growth hormone peak(GHP),insulin-like growth factor-1(IGF-1),and insulin-like growth factor binding protein 3(IGFBP3) in serum were conducted between the two groups. The incidence of adverse reactions during treatment was observed. Results:After twelve months of treatment,the HtSDS was larger than that in the control group,difference being significant(P<0.05).After six months and twelve months of treatment,the GV in the observation group were larger than those in the control group,and the levels of IGF-1 and IGFBP3 in serum were higher than those in the control group,differences being significant(P<0.05). After six months and twelve months of treatment,there were no significant differences being found in the comparison of height,BMI,CA/BA,and the level of GHP in serum between the two groups(P>0.05). No adverse reaction occurred in the two groups during treatment. Conclusion: The therapy of exercise combined with Buzhong Zhuzhang granules can effectively promote the growth of ISS children with safe clinical use,whose mechanism is probably related to its promotion on the increase of levels of IGF-1 and IGFBP3 in serum.

关 键 词：特发性矮小症 运动 补中助长颗粒 生长指标 血清胰岛素样生长因子-1 胰岛素样生长因子结合蛋白3 

分 类 号：R729[医药卫生—儿科]