补肾宁心方治疗心肾不交型早发性卵巢功能不全临床研究  

Clinical Study on Bushen Ningxin Prescription for Early-Onset Ovarian Insufficiency of Non-Interaction Between Heart and Kidney Type

作　　者：陈文俊 谈勇[2] CHEN Wenjun;TAN Yong

机构地区：[1]浙江中医药大学附属第一医院妇科,浙江杭州310006 [2]南京中医药大学,江苏南京210023

出　　处：《新中医》2020年第23期76-79,共4页New Chinese Medicine

基　　金：浙江省中医药优秀青年人才基金项目(2018ZQ021);浙江省中医药科技计划项目(2018ZA038)。

摘　　要：目的:观察补肾宁心方治疗心肾不交型早发性卵巢功能不全的临床疗效。方法:选取心肾不交型早发性卵巢功能不全患者60例,按随机数字表法分为对照组和观察组各30例。对照组给予芬吗通治疗,观察组给予补肾宁心方治疗,疗程均为3个月。比较2组治疗前后Kupperman评分、中医证候积分、卵泡刺激素(FSH)、黄体生成素(LH)、雌二醇(E2)、抗苗勒管激素(AMH)、5-羟色胺(5-HT)、卵巢体积、窦卵泡数、子宫内膜厚度、卵巢动脉阻力指数(RI)。结果:治疗前,2组Kupperman评分及中医证候积分比较,差异均无统计学意义(P>0.05)。治疗后,2组Kupperman评分及中医证候积分均较治疗前降低(P<0.05),且观察组Kupperman评分及中医证候积分均低于对照组(P<0.05)。治疗前,2组FSH、LH、E2、AMH、5-HT水平比较,差异均无统计学意义(P>0.05)。治疗后,2组FSH、LH较治疗前降低,E2、AMH较治疗前升高(P<0.05);观察组5-HT较治疗前升高(P<0.05)。治疗后,观察组FSH、LH均低于对照组,5-HT高于对照组(P<0.05)。治疗前,2组卵巢体积、窦卵泡数、子宫内膜厚度、RI比较,差异均无统计学意义(P>0.05)。治疗后,2组卵巢体积、窦卵泡数、子宫内膜厚度均高于治疗前(P<0.05)。结论:补肾宁心方可改善心肾不交型早发性卵巢功能不全患者的临床症状,改善激素水平,提高卵巢储备功能。Objective:To observe the clinical effect of Bushen Ningxin prescription for early-onset ovarian insufficiency of non-interaction between the heart and kidney type. Methods: A total of 60 cases of patients with early-onset ovarian insufficiency of non-interaction between the heart and kidney type were selected and divided into the control group and the observation group according to the random number table method,30 cases in each group. The control group was treated with Femoston,and the observation group was given Bushen Ningxin prescription. Both groups were treated for three months.Before and after treatment, Kupperman scores, Chinese medicine syndrome scores, follicle stimulating hormone(FSH),luteinizing hormone(LH),estradiol(E2),anti-müllerian hormone(AMH),5-hydroxytryptamine(5-HT),ovarian volume,the number of antral follicles,endometrial thickness,and the resistance index(RI) of ovarian artery were compared between two groups. Results:Before treatment,there were no significant differences being found in the comparison of Kupperman score and Chinese medicine syndrome score between the two groups(P>0.05). After treatment, the Kupperman scores and Chinese medicine syndrome scores in the two groups were decreased when compared with those before treatment(P < 0.05),and the two scores above in the observation group were lower than those in the control group(P<0.05). Before treatment,there were no significant differences being found in the comparison of the levels of FSH,LH,E2,AMH,and 5-HT between the two groups(P>0.05). After treatment,the levels of FSH and LH in the two groups were decreased when compared with those before treatment, and the levels of E2 and AMH were increased(P<0.05);the level of 5-HT in the observation group was increased when compared with that before treatment(P<0.05). After treatment,the levels of FSH and LH in the observation group were lower than those in the control group,and the level of 5-HT was higher(P<0.05). Before treatment,when compared the ovarian volume,the number of antral foll

关 键 词：早发性卵巢功能不全 补肾宁心方 心肾不交型 KUPPERMAN评分 中医证候积分 性激素 5-羟色胺 

分 类 号：R271.9[医药卫生—中西医结合]