益母草颗粒联合米非司酮、米索前列醇治疗药物流产后出血临床研究  

Clinical Study on Motherwort Granules Combined with Mifepristone and Misoprostol for Hemorrhage After Medical Abortion

作　　者：蔡东旭 陈毓敏 任桂玲 傅亚富 姚娟 CAI Dongxu;CHEN Yumin;REN Guiling;FU Yafu;YAO Juan

机构地区：[1]宁波市北仑区第三人民医院药剂科,浙江宁波315801 [2]宁波市北仑区第三人民医院妇科,浙江宁波315801

出　　处：《新中医》2020年第23期80-82,共3页New Chinese Medicine

摘　　要：目的:观察益母草颗粒联合米非司酮、米索前列醇对药物流产后出血的治疗效果。方法:将90例行药物流产的患者随机分为2组,每组45例。对照组采用米非司酮、米索前列醇治疗,观察组在对照组的基础上加用益母草颗粒治疗。疗程均为1周,观察比较2组孕囊排出时间、阴道出血时间、阴道出血量、血红蛋白水平以及子宫内膜厚度。结果:治疗后,观察组孕囊排出、阴道出血及月经恢复时间均显著短于对照组,差异有统计学意义(P<0.05)。观察组阴道出血量少的病例占55.56%,对照组阴道出血量少的病例占28.89%,2组比较,差异有统计学意义(P<0.05)。治疗前,观察组血红蛋白水平、子宫内膜厚度与对照组比较,差异均无统计学意义(P>0.05);治疗后,观察组患者血红蛋白水平高于对照组、子宫内膜厚度大于对照组,差异均有统计学意义(P<0.05)。结论:益母草颗粒联合米非司酮、米索前列醇用于药物流产效果显著,可有效减少出血量,恢复子宫内膜厚度,纠正患者贫血状态。Objective:To observe the curative effect of motherwort granules combined with mifepristone and misoprostol for hemorrhage after medical abortion. Methods:A total of 90 cases of patients undergoing medical abortion were randomly divided into two groups,45 cases in each group. The control group was treated with mifepristone and misoprostol,and the observation group was additionally treated with motherwort granules based on the treatment of the control group. Both groups were treated for one week. The time of gestational sac discharge, vaginal bleeding time, vaginal bleeding volume,hemoglobin levels and endometrial thickness in the two groups were observed and compared. Results:After treatment,the time of gestational sac discharge, vaginal bleeding and menstruation recovery in the observation group was significantly shorter than that in the control group,the difference being significant(P<0.05). Cases with a small amount of vaginal bleeding accounted for 55.56% in the observation group and 28.89% in the control group,the difference being significant(P<0.05).Before treatment,there were no significant difference being found in the comparison of hemoglobin levels and endometrial thickness between the two groups(P>0.05);after treatment,the hemoglobin level in the observation group was higher than that in the control group, and endometrial thickness was larger, differences being significant(P<0.05). Conclusion: The application of motherwort granules combined with mifepristone and misoprostol has significant effect in medical abortion,which can significantly reduce blood loss,restore endometrial thickness and correct anemia in patients.

关 键 词：药物流产 米非司酮 米索前列醇 益母草颗粒 

分 类 号：R714.21[医药卫生—妇产科学]