温脾补肾固精方治疗原发性肾病综合征临床研究  

Clinical Study on Wenpi Bushen Gujing Prescription for Primary Nephrotic Syndrome

作　　者：韩君 林咸楚 张莉 娄万爽 麻黎青 HAN Jun;LIN Xianchu;ZHANG Li;LOU Wanshuang;MA Liqing

机构地区：[1]三门县人民医院,浙江三门318000

出　　处：《新中医》2020年第23期85-88,共4页New Chinese Medicine

摘　　要：目的:观察温脾补肾固精方治疗原发性肾病综合征(PNS)的临床疗效,以及对T淋巴细胞亚群及血清免疫球蛋白水平的影响。方法:将80例PNS患者按随机数字表法分为对照组和观察组各40例。对照组采用激素治疗,观察组在对照组基础上联用温脾补肾固精方治疗,2组均治疗6个月。比较2组治疗前后T淋巴细胞亚群、免疫球蛋白A (IgA)、IgG、IgM、24 h尿蛋白、白蛋白(Alb)、中医证候积分、临床疗效和不良反应情况。结果:观察组总有效率为90.00%,高于对照组72.50%(P<0.05)。治疗前,2组CD3+、CD4+、CD8+、CD4+/CD8+、IgA、IgG、IgM、24 h尿蛋白、Alb水平比较,差异均无统计学意义(P>0.05)。治疗后,对照组CD4+/CD8+、24 h尿蛋白水平低于治疗前,CD8+、IgG、Alb水平高于治疗前(P<0.05);观察组CD3+、CD4+、CD4+/CD8+、IgG、Alb水平高于治疗前和对照组(P<0.05),CD8+、IgM、24 h尿蛋白水平低于治疗前和对照组(P<0.05)。治疗前,2组腰膝酸软、面身浮肿、畏寒肢冷、食少纳呆、面色?白、性欲减退、神疲乏力、大便溏稀评分及总积分比较,差异均无统计学意义(P>0.05)。治疗后,2组腰膝酸软、面身浮肿、畏寒肢冷、食少纳呆、面色?白、性欲减退、神疲乏力、大便溏稀评分及总积分较治疗前降低,且观察组各项症状评分均低于对照组,差异均有统计学意义(P<0.05)。观察组不良反应发生率为10.00%,低于对照组32.50%(P<0.05)。结论:温脾补肾固精方治疗PNS疗效显著,可提高免疫功能,并减少激素引起的不良反应。Objective:To observe the clinical effect of Wenpi Bushen Gujing prescription for primary nephrotic syndrome(PNS) and its effect on T lymphocyte subsets and serum immunoglobulin levels. Methods:A total of 80 cases of PNS patients were divided into the control group and the observation group according to the random number table method,40 cases in each group. The control group was treated with hormones,and the observation group was additionally treated with Wenpi Bushen Gujing prescription based on the treatment of the control group. Both groups were treated for six months. Before and after treatment, T lymphocyte subsets, immunoglobulin A(Ig A), Ig G, Ig M, 24 h urinary protein, albumin(Alb), Chinese medicine syndrome scores, clinical effect and adverse reactions in the two groups were compared. Results: The total effective rate was 90.00% in the observation group, higher than that of 72.50% in the control group(P<0.05). Before treatment, there was no significant difference being found in the comparison of the levels of CD3^+, CD4^+, CD8+,CD4^+/CD8^+,Ig A,Ig G,Ig M,24 h urinary protein and Alb between the two groups(P>0.05). After treatment,the levels of CD4^+/CD8^+and 24 h urinary protein in the control group were lower than those before treatment,and the levels of CD8+,Ig G and Alb were higher(P<0.05);the levels of CD3^+,CD4^+,CD4^+/CD8^+,Ig G and Alb in the observation group were higher than those before treatment and those in the control group(P<0.05),and the levels of CD8+,Ig M and 24 h urinary protein were lower(P<0.05). Before treatment, there was no significant difference being found in the comparison of the scores of lassitude in loin and legs, puffy face and body, fear of cold and cold limbs, poor appetite and torpid intake, bright pale complexion,hyposexuality,lassitude of spirit and lack of strength and pond dilute stool as well as the total scores between the two groups(P>0.05). After treatment,the above scores in the two groups were decreased when compared with those before treatment, and all the symp

关 键 词：原发性肾病综合征 脾肾阳虚证 温脾补肾固精方 T淋巴细胞 免疫球蛋白 

分 类 号：R692[医药卫生—泌尿科学]